ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Behavioral Role of the Reciprocal Inhibition between a Pair of Mauthner Cells during Fast Escapes in Zebrafish.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 33 citations in OpenAlex.
- Comparative Investigations of the Neurophysiological Mechanisms of Escape Behavior: A Course-based Undergraduate Research Experience.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2026Article
- Spatially ordered recruitment of fast muscles in accordance with movement strengths in larval zebrafish.Zoological letters · 2025Article
- Defects in Exosome Biogenesis Are Associated with Sensorimotor Defects in ZebrafishThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Celsr3 drives development and connectivity of the acoustic startle hindbrain circuit.PLoS genetics · 2024Article
- Assessing the effects of fluorine-free and PFAS-containing firefighting foams on development and behavioral responses using a zebrafish-based platform.Chemosphere · 2024Article
- Celsr3 drives development and connectivity of the acoustic startle hindbrain circuit.bioRxiv : the preprint server for biology · 2024Article
- Biomechanics and neural circuits for vestibular-induced fine postural control in larval zebrafish.Nature communications · 2023Article
- Long descending commissural V0v neurons ensure coordinated swimming movements along the body axis in larval zebrafish.Scientific reports · 2022Article
- Intrinsic brainstem circuits comprised of Chx10-expressing neurons contribute to reticulospinal output in mice.Journal of neurophysiology · 2021Article
- A specialized spinal circuit for command amplification and directionality during escape behavior.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Different microcircuit responses to comparable input from one versus both copies of an identified projection neuron.The Journal of experimental biology · 2020Article
- Dynamics of a neuronal pacemaker in the weakly electric fish Apteronotus.Scientific reports · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During many behaviors in vertebrates, the CNS generates asymmetric activities between the left and right sides to produce asymmetric body movements. For asymmetrical activations of the CNS, reciprocal inhibition between the left and right sides is believed to play a key role. However, the complexity of the CNS makes it difficult to identify the reciprocal inhibition circuits at the level of individual cells and the contribution of each neuron to the asymmetric activity. Using larval zebrafish, we examined this issue by investigating reciprocal inhibition circuits between a pair of Mauthner (M) cells, giant reticulospinal neurons that trigger fast escapes. Previous studies have shown that a class of excitatory neurons, called cranial relay neurons, is involved in the reciprocal inhibition pathway between the M cells. Using transgenic fish, in which two of the cranial relay neurons (Ta1 and Ta2) expressed GFP, we showed that Ta1 and Ta2 constitute major parts of the pathway. In larvae in which Ta1/Ta2 were laser-ablated, the amplitude of the reciprocal IPSPs dropped to less than one-third. Calcium imaging and electrophysiological recording showed that the occurrence probability of bilateral M-cell activation upon sound/vibration stimuli was greatly increased in the Ta1/Ta2-ablated larvae. Behavioral experiments revealed that the Ta1/Ta2 ablation resulted in shallower body bends during sound/vibration-evoked escapes, which is consistent with the observation that increased occurrence of bilateral M-cell activation impaired escape performance. Our study revealed major components of the reciprocal inhibition circuits in the M cell system and the behavioral importance of the circuits.
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