Evidence map›Paper›PMID 30578318›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

On the mechanisms of conjugate vaccines.

Rino Rappuoli, Ennio De Gregorio, Paolo Costantino

Abstract readComment
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Typhoid conjugate vaccines for preventing typhoid fever (enteric fever).The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Disparate kinetics in immune response of two differentHuman vaccines & immunotherapeutics · 2024
    Trial
  3. Trial
  4. Article
  5. Article
  6. Journal of bacteriology · 2026
    Review
  7. Microorganisms · 2026
    Review
  8. Article
  9. Article
  10. Journal of preventive medicine and hygiene · 2026
    Article
  11. Review
  12. Article
  13. Review
  14. Carbohydrate Chemistry II.Molecules (Basel, Switzerland) · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Rino RappuoliR&D Centre, GlaxoSmithKline, 53100 Siena, Italy; rino.r.rappuoli@gsk.com.ORCID 0000-0002-8827-254X
Ennio De GregorioR&D Centre, GlaxoSmithKline, 53100 Siena, Italy.
Paolo CostantinoPrivate address, 53034 Colle Val d'Elsa (SI), Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Pneumococcal VaccinesVaccines, ConjugateAdaptive ImmunityGlycoconjugatesMeningococcal VaccinesPolysaccharidesGlycoconjugatesMeningococcal VaccinesPneumococcal VaccinesPolysaccharidesVaccines, Conjugate

Identifiers

PMID30578318
PMCPMC6320500

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.