Evidence map›Paper›PMID 30578300›Full record

ArticleThe Journal of biological chemistry2019

Application of high-throughput, capillary-based Western analysis to modulated cleavage of the cellular prion protein.

Andrew R Castle, Nathalie Daude, Sabine Gilch, David Westaway

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  4. Review
  5. Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein.Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Andrew R CastleFrom the Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta T6G 2M8, Canada.
Nathalie DaudeFrom the Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta T6G 2M8, Canada.
Sabine GilchDepartment of Ecosystem and Public Health, Calgary Prion Research Unit, Faculty of Veterinary Medicine and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada, and.
David WestawayFrom the Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta T6G 2M8, Canada david.westaway@ualberta.ca.ORCID 0000-0003-1928-4616
University of Alberta · CAUniversity of Calgary · CA

Funding

CIHR MOP123525CIHR MOP137094
6 · The paper itself

Abstract

The cellular prion protein (PrP

Indexed as

AnimalsBlotting, WesternBrainEpithelial CellsHigh-Throughput Screening AssaysKidneyMiceMice, TransgenicProteolysisPrPC ProteinsRabbitsPrPC Proteinscapillary Westernglycoproteinhigh-throughput screening (HTS)neurodegenerationprion diseaseprotein misfoldingproteolysisPrPCsimple Western

Identifiers

PMID30578300
PMCPMC6393610
OpenAlexW2905639080

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.