Evidence map›Paper›PMID 30578285›Full record

ArticleRNA (New York, N.Y.)2019

Conformational flexibility in the enterovirus RNA replication platform.

Meghan S Warden, Kai Cai, Gabriel Cornilescu, Jordan E Burke, Komala Ponniah, Samuel E Butcher, Steven M Pascal

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Meghan S WardenDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia 23529, USA.
Kai CaiDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
Gabriel CornilescuNational Magnetic Resonance Facility at Madison (NMRFAM), University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
Jordan E BurkeDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
Komala PonniahDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia 23529, USA.
Samuel E ButcherDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
Steven M PascalDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia 23529, USA spascal@odu.edu.
University of Wisconsin–Madison · USOld Dominion University · US

Funding

TR&D 3: TECHNOLOGY DEVELOPMENT FOR NMR STUDIES OF SMALL MOLECULES (METABOLOMICS, NATURAL PRODUCTS, METABOLITE-PROTEIN INTERACTIONS) pp.537-585 P41GM103399 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BUTCHER, SAMUEL E · 2012 to 2019
$9.4M
Biophysical investigations of RNA complexes essential for gene expressionR35GM118131 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Samuel E Butcher · 2016 to 2026
$5.1M
Integrated state-of-the-art LC-MS/NMR system for the University of WisconsinS10RR025062 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 2008 to 2008
$1.7M
Upgrade of the NMRFAM 750 MHz NMR SpectrometerS10RR029220 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 2010 to 2010
$766k
NMR Spectrometer System Optimized for Direct 13C or 15N DetectionS10RR023438 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 2008 to 2008
$500k
CONSOLE UPGRADES FOR NMR FACILITYS10RR008438 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI MARKLEY, JOHN L · 1993 to 1993
–
WIDE-BORE 9.4 TESLA NMR SPECTROMETER FOR UW-MADISONS10RR002781 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI MARKLEY, JOHN L · 1986 to 1986
–
NCRR NIH HHS S10 RR002781NCRR NIH HHS S10 RR008438NCRR NIH HHS S10 RR023438NCRR NIH HHS S10 RR025062NCRR NIH HHS S10 RR029220NIGMS NIH HHS P41 GM103399NIGMS NIH HHS R35 GM118131NIH HHS P41GM103399NIH HHS R35GM118131NIH HHS S10RR023438NIH HHS S10RR025062NIH HHS S10RR02781NIH HHS S10RR029220NIH HHS S10RR08438
6 · The paper itself

Abstract

A presumed RNA cloverleaf (5'CL), located at the 5'-most end of the noncoding region of the enterovirus genome, is the primary established site for initiation of genomic replication. Stem-loop B (SLB) and stem-loop D (SLD), the two largest stem-loops within the 5'CL, serve as recognition sites for protein interactions that are essential for replication. Here we present the solution structure of rhinovirus serotype 14 5'CL using a combination of nuclear magnetic resonance spectroscopy and small-angle X-ray scattering. In the

Indexed as

Nucleic Acid ConformationTranscription, GeneticEnterovirusGene Expression Regulation, ViralMagnesiumMagnetic Resonance SpectroscopyModels, MolecularRNA, ViralStructure-Activity RelationshipVirus ReplicationMagnesiumRNA, ViralcloverleafenterovirusNMRreplicationRNASAXS

Identifiers

PMID30578285
PMCPMC6380274
OpenAlexW2906263718

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.