Evidence map›Paper›PMID 30578283›Full record

ArticleThe Journal of cell biology2019

Rab5 GTPases are required for optimal TORC2 function.

Melissa N Locke, Jeremy Thorner

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Rabs in Signaling and Embryonic Development.International journal of molecular sciences · 2020
    Review
  7. Analysis of the roles of phosphatidylinositol-4,5-Molecular biology of the cell · 2019
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Melissa N LockeDivision of Biochemistry, Biophysics, and Structural Biology and Division of Cell and Developmental Biology, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA.ORCID 0000-0001-8162-1471
Jeremy ThornerDivision of Biochemistry, Biophysics, and Structural Biology and Division of Cell and Developmental Biology, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA jthorner@berkeley.edu.ORCID 0000-0002-2583-500X
University of California, Berkeley · US

Funding

THE MOLECULAR BASIS OF CELL FUNCTIONT32GM007232 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BILDER, DAVID, UNAL, ELCIN · 1985 to 2022
$36.4M
Yeast Protein Kinase Signaling Networks: Specificity, Regulation and FunctionR01GM021841 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI THORNER, JEREMY W. · 1985 to 2019
$11.8M
NIGMS NIH HHS R01 GM021841NIGMS NIH HHS T32 GM007232
6 · The paper itself

Abstract

Target of rapamycin complex-2 (TORC2), a conserved protein kinase complex, is an indispensable regulator of plasma membrane homeostasis. In budding yeast (

Indexed as

Glycogen Synthase Kinase 3Guanine Nucleotide Exchange FactorsMechanistic Target of Rapamycin Complex 2Protein Kinasesrab5 GTP-Binding Proteinsrab GTP-Binding ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsVesicular Transport ProteinsGlycogen Synthase Kinase 3Guanine Nucleotide Exchange FactorsMCK1 protein, S cerevisiaeMechanistic Target of Rapamycin Complex 2Muk1 protein, S cerevisiaeProtein Kinasesrab5 GTP-Binding Proteinsrab GTP-Binding ProteinsSaccharomyces cerevisiae ProteinsVesicular Transport ProteinsVPS21 protein, S cerevisiaeVPS9 protein, S cerevisiaeYPK2 protein, S cerevisiae

Identifiers

PMID30578283
PMCPMC6400565
OpenAlexW2906662594

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.