Evidence map›Paper›PMID 30578252›Full record

ArticleBiology open2019

The role of retrograde intraflagellar transport genes in aminoglycoside-induced hair cell death.

Tamara M Stawicki, Tor Linbo, Liana Hernandez, Lauren Parkinson, Danielle Bellefeuille, Edwin W Rubel, David W Raible

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Frontiers in pharmacology · 2024
    Article
  3. Hair cell toxicology: With the help of a little fish.Frontiers in cell and developmental biology · 2022
    Review
  4. Article
  5. Cilia in the developing zebrafish ear.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tamara M StawickiProgram in Neuroscience, Lafayette College, Easton, PA 18042, USA stawickt@lafayette.edu.ORCID http://orcid.org/0000-0003-2191-8550
Tor LinboDepartment of Biological Structure, University of Washington, Seattle, WA 98195, USA.
Liana HernandezDepartment of Biological Structure, University of Washington, Seattle, WA 98195, USA.ORCID http://orcid.org/0000-0002-3018-1792
Lauren ParkinsonProgram in Neuroscience, Lafayette College, Easton, PA 18042, USA.
Danielle BellefeuillePsychology Department, Lafayette College, Easton, PA 18042, USA.
Edwin W RubelVirginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, WA 98195, USA.
David W RaibleDepartment of Biological Structure, University of Washington, Seattle, WA 98195, USA.
University of Washington · USLafayette College · US

Funding

Genetics of Zebrafish Hair Cell ToxicityR01DC005987 · NIDCD · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 2003 to 2023
$9.8M
Retrograde intraflagellar transport genes in aminoglycoside-induced hair cell deathR03DC015080 · NIDCD · UNIVERSITY OF WASHINGTON · PI STAWICKI, TAMARA M · 2015 to 2017
$431k
NIDCD NIH HHS R01 DC005987NIDCD NIH HHS R03 DC015080
6 · The paper itself

Abstract

Sensory hair cells are susceptible to numerous insults, including certain therapeutic medications like aminoglycoside antibiotics, and hearing and balance disorders are often a dose-limiting side effect of these medications. We show that mutations in multiple genes in both the retrograde intraflagellar transport (IFT) motor and adaptor complexes lead to resistance to aminoglycoside-induced hair cell death. These mutations also lead to defects in the entry of both aminoglycosides and the vital dye FM1-43 into hair cells, both processes that depend on hair cell mechanotransduction activity. However, the trafficking of proteins important for mechanotransduction activity is not altered by these mutations. Our data suggest that both retrograde IFT motor and adaptor complex genes are playing a role in aminoglycoside toxicity through affecting aminoglycoside uptake into hair cells.

Indexed as

AminoglycosidesCiliaHair cellsIntraflagellar transportOtotoxicity

Identifiers

PMID30578252
PMCPMC6361216
OpenAlexW2906351923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.