Evidence map›Paper›PMID 30578088›Full record

ArticleVaccine2019

The potential effects of introducing microneedle patch vaccines into routine vaccine supply chains.

Patrick T Wedlock, Elizabeth A Mitgang, Fayad Elsheikh, Jim Leonard, Jenn Bakal, Joel Welling, Jessica Crawford, Emmanuelle Assy, Bvudzai P Magadzire, Ruth Bechtel and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Patrick T WedlockGlobal Obesity Prevention Center (GOPC) at Johns Hopkins University, Baltimore, MD, USA; HERMES Logistics Modeling Team, Baltimore, MD and Pittsburgh, PA, USA.
Elizabeth A MitgangGlobal Obesity Prevention Center (GOPC) at Johns Hopkins University, Baltimore, MD, USA; HERMES Logistics Modeling Team, Baltimore, MD and Pittsburgh, PA, USA.
Fayad ElsheikhHERMES Logistics Modeling Team, Baltimore, MD and Pittsburgh, PA, USA.
Jim LeonardHERMES Logistics Modeling Team, Baltimore, MD and Pittsburgh, PA, USA; Pittsburgh Supercomputing Center (PSC), Pittsburgh, PA, USA.
Jenn BakalHERMES Logistics Modeling Team, Baltimore, MD and Pittsburgh, PA, USA; Pittsburgh Supercomputing Center (PSC), Pittsburgh, PA, USA.
Joel WellingHERMES Logistics Modeling Team, Baltimore, MD and Pittsburgh, PA, USA; Pittsburgh Supercomputing Center (PSC), Pittsburgh, PA, USA.
Jessica CrawfordVillageReach, Seattle, WA, USA.
Emmanuelle AssyVillageReach, Seattle, WA, USA.
Bvudzai P MagadzireVillageReach, Seattle, WA, USA.
Ruth BechtelVillageReach, Seattle, WA, USA.
Jay V DePasseHERMES Logistics Modeling Team, Baltimore, MD and Pittsburgh, PA, USA; Pittsburgh Supercomputing Center (PSC), Pittsburgh, PA, USA.
Sheryl S SiegmundGlobal Obesity Prevention Center (GOPC) at Johns Hopkins University, Baltimore, MD, USA; HERMES Logistics Modeling Team, Baltimore, MD and Pittsburgh, PA, USA.
Shawn T BrownHERMES Logistics Modeling Team, Baltimore, MD and Pittsburgh, PA, USA; McGill Centre for Integrative Neuroscience, McGill Neurological Institute, McGill University, Montreal, Canada.
Bruce Y LeeGlobal Obesity Prevention Center (GOPC) at Johns Hopkins University, Baltimore, MD, USA; HERMES Logistics Modeling Team, Baltimore, MD and Pittsburgh, PA, USA. Electronic address: brucelee@jhu.edu.
Health and Education Research Management and Epidemiologic Services (United States) · USVillageReach · USPittsburgh Supercomputing Center · USJohns Hopkins University · USMcGill University · CA

Funding

MULTILEVEL SYSTEMS-ORIENTED CHILDHOOD OBESITY STUDY IN CHINAU54HD070725 · NICHD · JOHNS HOPKINS UNIVERSITY · PI WANG, YOUFA · 2011 to 2016
$15.9M
MIDAS Informatics Services Group (ISG)U24GM110707 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ESPINO, JESSI U, WAGNER, MICHAEL MATTHEW · 2014 to 2018
$11.6M
Regional Healthcare Ecosystem Analyst for Healthcare Associated InfectionsR01HS023317 · AHRQ · JOHNS HOPKINS UNIVERSITY · PI LEE, BRUCE Y · 2014 to 2014
$2.4M
AHRQ HHS R01 HS023317NICHD NIH HHS U54 HD070725NIGMS NIH HHS U24 GM110707
6 · The paper itself

Abstract

backgroundMicroneedle patch (MNP) technology is designed to simplify the process of vaccine administration; however, depending on its characteristics, MNP technology may provide additional benefits beyond the point-of-use, particularly for vaccine supply chains.

methodsUsing the HERMES modeling software, we examined replacing four routine vaccines - Measles-containing vaccine (MCV), Tetanus toxoid (TT), Rotavirus (Rota) and Pentavalent (Penta) - with MNP versions in the routine vaccine supply chains of Benin, Bihar (India), and Mozambique.

resultsReplacing MCV with an MNP (5 cm

conclusionsAn MNP for MCV, TT, Rota, or Penta would need to have a smaller or equal volume-per-dose than existing vaccine formulations and be able to be stored outside the cold chain for a continuous period of at least two months to provide additional benefits to all three supply chains under modeled conditions.

Indexed as

Drug Delivery SystemsMicroinjectionsTransdermal PatchBeninCosts and Cost AnalysisHumansImmunization ProgramsIndiaInfluenza VaccinesMozambiqueRefrigerationRotavirus VaccinesTetanus ToxoidVaccinationVaccinesInfluenza VaccinesRotavirus VaccinesTetanus ToxoidVaccinesDeliveryLogisticsMicroneedle patchSupply chain

Identifiers

PMID30578088
PMCPMC6559242
OpenAlexW2905066720

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.