ReviewPsychoneuroendocrinology2019
Translating basic research knowledge on the biological embedding of early-life stress into novel approaches for the developmental programming of lifelong health.
Review in Psychoneuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed.
- Moving the dial on prenatal stress mechanisms of neurodevelopmental vulnerability to mental health problems: A personalized prevention proof of concept.Developmental psychobiology · 2021Trial
- Environmental determinants of physiological reactivity to stress: The interacting effects of early life deprivation, caregiving quality, and stressful life events.Development and psychopathology · 2020Trial
- Parenting and Child/Adolescent Development: Current Updates and Global Perspectives: Second Edition.Children (Basel, Switzerland) · 2026Article
- Glucose as fuel for HPA axis regulation: A narrative review on energy metabolism, stress reactivity, and early life adversity.Comprehensive psychoneuroendocrinology · 2026Review
- Early Life Stress and Adversity in Children: Neuroendocrine Mechanisms, Epigenetic Regulation, and Lifespan Developmental Outcomes-A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Early-life adversity in rodents: Experimental design is of the essence.Neurobiology of stress · 2026Article
- Childhood adversity, benevolent experiences, and perceived stress among pregnant women in Mexico: psychosocial determinants of maternal well-being in a middle-income setting.BMC pregnancy and childbirth · 2026Observational
- Ageing reveals the latent effects of early life stress on respiratory and metabolic function in female rats: Novel insights into the sex-specific origins of sleep apnoea.Experimental physiology · 2026Article
- Childhood experiences and adult self-rated physical health in 22 countries.BMC global and public health · 2026Article
- Early life stress enhances the association between residential nature exposure and fasting blood glucose.PloS one · 2026Article
- The role of perinatal perceived stress in the setting of adverse childhood experience and perinatal anxiety and depressive symptoms.BMC psychology · 2025Article
- Maternal history of maltreatment interacts with DNA methylation patterns to predict infant temperament.Child abuse & neglect · 2025Article
- Long-term alteration of heart rate variability following childhood maltreatment: Results of a general population study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Early-Life Adversity Predicts Markers of Aging-Related Neuroinflammation, Neurodegeneration, and Cognitive Impairment in Women.Annals of neurology · 2025Article
- The effect of mortality salience and early-life maternal care on neuroendocrine, autonomic, and psychological stress responses.Scientific reports · 2025Article
- Article
- A Brief Historic Review of Research on Early Life Stress and Inflammation across the Lifespan.Neuroimmunomodulation · 2025Review
- Autoimmune Thyroid Disease and Pregnancy: The Interaction Between Genetics, Epigenetics and Environmental Factors.Journal of clinical medicine · 2024Review
- Epigenetics Embedding of Oral Feeding Skill Development in Preterm Infants: A Study Protocol.Advances in neonatal care : official journal of the National Association of Neonatal Nurses · 2024Article
- [Psychotherapeutic approaches to crises].Der Nervenarzt · 2024Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
This review integrates scientific knowledge obtained over the past few decades on the biological mechanisms that contribute to the profound association between exposure to early adversity, including childhood trauma and prenatal stress, and the lifelong elevated risk to develop a broad range of diseases. We further discuss insights into gene-environment interactions moderating the association between early adversity and disease manifestation and we discuss the role of epigenetic and other molecular processes in the biological embedding of early adversity. Based on these findings, we propose potential mechanisms that may contribute to the intergenerational transmission of risk related to early adversity from the mother to the fetus. Finally, we argue that basic research knowledge on the biological embedding of early adversity must now be translated into novel intervention strategies that are mechanism-driven and sensitive to developmental timing. Indeed, to date, there are no diagnostic biomarkers of risk or mechanism-informed interventions that we can offer to victims of early adversity in order to efficiently prevent or reverse adverse health outcomes. Such translational efforts can be expected to have significant impact on both clinical practice and the public health system, and will promote precision medicine in pediatrics and across the lifespan.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.