ArticleBMC genomics2018
High-density SNP linkage map construction and QTL mapping for flavonoid-related traits in a tea plant (Camellia sinensis) using 2b-RAD sequencing.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 56 citations in OpenAlex.
- Advances in tea breeding in Japan: from traditional methods to genomic approaches.Breeding science · 2026Article
- Cytological Observation of Distant Hybridization Barrier and Preliminary Investigation of Hybrid Offspring in Tea Plants.Plants (Basel, Switzerland) · 2025Article
- Two shikimate dehydrogenases play an essential role in the biosynthesis of galloylated catechins in tea plants.Horticulture research · 2025Article
- Genetic diversity analysis and core germplasm construction of tea plants in Lu'an.BMC plant biology · 2025Article
- Identification of key genes associated with anthracnose resistance in Camellia sinensis.PloS one · 2025Article
- Analysis of the mitochondrial genome of theFrontiers in plant science · 2025Article
- Article
- Application of Multi-Perspectives in Tea Breeding and the Main Directions.International journal of molecular sciences · 2023Review
- Identification of QTL controlling volatile terpene contents in tea plant (Frontiers in plant science · 2023Article
- Nitrogen transport and assimilation in tea plant (Frontiers in plant science · 2023Review
- The Current Developments in Medicinal Plant Genomics Enabled the Diversification of Secondary Metabolites' Biosynthesis.International journal of molecular sciences · 2022Review
- Development of a genome-wide 200K SNP array and its application for high-density genetic mapping and origin analysis of Camellia sinensis.Plant biotechnology journal · 2022Article
- Quantitative trait loci mapping for free amino acid content using an albino population and SNP markers provides insight into the genetic improvement of tea plants.Horticulture research · 2022Article
- Genetic analysis of the early bud flush trait of tea plants (Horticulture research · 2022Article
- Construction of ultra-high-density genetic linkage map of a sorghum-sudangrass hybrid using whole genome resequencing.PloS one · 2022Article
- Genome-wide association analysis identified molecular markers associated with important tea flavor-related metabolites.Horticulture research · 2021Article
- A functional molecular marker for detecting blister blight disease resistance in tea (Camellia sinensis L.).Plant cell reports · 2021Article
- Omics Technologies to Enhance Plant Based Functional Foods: An Overview.Frontiers in genetics · 2021Review
- QTL Mapping for Leaf Area of Tea Plants (Frontiers in plant science · 2021Article
- The chromosome-scale genome reveals the evolution and diversification after the recent tetraploidization event in tea plant.Horticulture research · 2020Article
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6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundFlavonoids are important components that confer upon tea plants a unique flavour and health functions. However, the traditional breeding method for selecting a cultivar with a high or unique flavonoid content is time consuming and labour intensive. High-density genetic map construction associated with quantitative trait locus (QTL) mapping provides an effective way to facilitate trait improvement in plant breeding. In this study, an F1 population (LJ43×BHZ) was genotyped using 2b-restriction site-associated DNA (2b-RAD) sequencing to obtain massive single nucleotide polymorphism (SNP) markers to construct a high-density genetic map for a tea plant. Furthermore, QTLs related to flavonoids were identified using our new genetic map.
resultsA total of 13,446 polymorphic SNP markers were developed using 2b-RAD sequencing, and 4,463 of these markers were available for constructing the genetic linkage map. A 1,678.52-cM high-density map at an average interval of 0.40 cM with 4,217 markers, including 427 frameset simple sequence repeats (SSRs) and 3,800 novel SNPs, mapped into 15 linkage groups was successfully constructed. After QTL analysis, a total of 27 QTLs related to flavonoids or caffeine content (CAF) were mapped to 8 different linkage groups, LG01, LG03, LG06, LG08, LG10, LG11, LG12, and LG13, with an LOD from 3.14 to 39.54, constituting 7.5% to 42.8% of the phenotypic variation.
conclusionsTo our knowledge, the highest density genetic map ever reported was constructed since the largest mapping population of tea plants was adopted in present study. Moreover, novel QTLs related to flavonoids and CAF were identified based on the new high-density genetic map. In addition, two markers were located in candidate genes that may be involved in flavonoid metabolism. The present study provides valuable information for gene discovery, marker-assisted selection breeding and map-based cloning for functional genes that are related to flavonoid content in tea plants.
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