ArticleBMC veterinary research2018
The prevalence and genomic characteristics of hepatitis E virus in murine rodents and house shrews from several regions in China.
Article in BMC veterinary research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- Viral pathogens in urban rats: A one health systematic review of global surveillance evidence.One health (Amsterdam, Netherlands) · 2026Review
- Rocahepevirus ratti: molecular evolution, zoonotic potential and public health impact.Nature communications · 2026Review
- Burden of rodent-borne viruses in rodents and zoonotic risk in humans in Cambodia.Microbiology spectrum · 2026Article
- Prevalence, Risk Factors, and Genetic Evolution of Rat Hepatitis E Virus in Small Mammals from Southwestern Yunnan, China.Biology · 2025Article
- Prevalence ofJHEP reports : innovation in hepatology · 2025Article
- Substantial spillover burden of rat hepatitis E virus in humans.Nature communications · 2025Article
- Trends and Challenges in the Detection and Environmental Surveillance of the Hepatitis E Virus.Microorganisms · 2025Review
- Diversity of Hepatitis E Viruses in Rats in Yunnan Province and the Inner Mongolia Autonomous Region of China.Viruses · 2025Article
- Identification of novel rodent and shrew orthohepeviruses sheds light on hepatitis E virus evolution.Zoological research · 2025Article
- Seroprevalence and risk factors of hantavirus and hepatitis E virus exposure among wildlife farmers in Vietnam.PloS one · 2025Article
- Ancient evolutionary origins of hepatitis E virus in rodents.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Investigating the Hepatitis E Virus (HEV) Diversity in Rat Reservoirs from Northern Italy.Pathogens (Basel, Switzerland) · 2024Article
- Detection of Virus-Related Sequences Associated With Potential Etiologies of Hepatitis in Liver Tissue Samples From Rats, Mice, Shrews, and Bats.Frontiers in microbiology · 2021Article
- Article
- Review
- Host Prdx6 contributing to the intracellular survival of Brucella suis S2 strain.BMC veterinary research · 2019Article
- Animal Models for Hepatitis E virus.Viruses · 2019Review
- The Current Host Range of Hepatitis E Viruses.Viruses · 2019Review
- Molecular Detection and Genetic Characterization of Novel RNA Viruses in Wild and Synanthropic Rodents and Shrews in Kenya.Frontiers in microbiology · 2019Article
- First evidence of hepatitis E virus infection in a small mammal (yellow-necked mouse) from Croatia.PloS one · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundUrban rodents and house shrews are closely correlated in terms of location with humans and can transmit many pathogens to them. Hepatitis E has been confirmed to be a zoonotic disease. However, the zoonotic potential of rat HEV is still unclear. The aim of this study was to determine the prevalence and genomic characteristics of hepatitis E virus (HEV) in rodents and house shrews.
resultsWe collected a total of 788 animals from four provinces in China. From the 614 collected murine rodents, 20.19% of the liver tissue samples and 45.76% of the fecal samples were positive for HEV. From the 174 house shrews (Suncus murinus), 5.17% fecal samples and 0.57% liver tissue samples were positive for HEV. All of the HEV sequences obtained in this study belonged to Orthohepevirus C1. However, we observed a lower percentage of identity in the ORF3 region upon comparing the amino acid sequences between Rattus norvegicus and Rattus losea. HEV derived from house shrews shared a high percentage of identity with rat HEV. Notably, the first near full-length of the HEV genome from Rattus losea is described in our study, and we also report the first near full-length rat HEV genomes in Rattus norvegicus from China.
conclusionHEV is prevalent among the three common species of murine rodents (Rattus. norvegicus, Rattus. tanezumi, and Rattus. losea) in China. HEV sequences detected from house shrews were similar to rat HEV sequences. The high identity of HEV from murine rodents and house shrews suggested that HEV can spread among different animal species.
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