Evidence map›Paper›PMID 30577733›Full record

ArticleScandinavian journal of trauma, resuscitation and emergency medicine2018

Effects of NaHS and hydroxylamine on the expressions of brain-derived neurotrophic factor and its receptors in rats after cardiac arrest and cardiopulmonary resuscitation.

Jiyan Lin, Weicheng Wu, Zhihong Xu, Siyao Liu, Wang Lu, Mandong Pan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Hydrogen Sulfide (HInternational journal of molecular sciences · 2025
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jiyan LinEmergency Department, The First Affiliated Hospital of Xiamen University, No 55, Zhenhai Rd, Xiamen, 361003, China. happylinjiy@163.com.
Weicheng WuEmergency Department, The First Affiliated Hospital of Xiamen University, No 55, Zhenhai Rd, Xiamen, 361003, China.
Zhihong XuEmergency Department, The First Affiliated Hospital of Xiamen University, No 55, Zhenhai Rd, Xiamen, 361003, China.
Siyao LiuEmergency Department, The First Affiliated Hospital of Xiamen University, No 55, Zhenhai Rd, Xiamen, 361003, China.
Wang LuEmergency Department, The First Affiliated Hospital of Xiamen University, No 55, Zhenhai Rd, Xiamen, 361003, China.
Mandong PanEmergency Department, The First Affiliated Hospital of Xiamen University, No 55, Zhenhai Rd, Xiamen, 361003, China. panmd117@139.com.
First Affiliated Hospital of Xiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundH

methodsRats (n = 240) with CA/CPR were divided into three groups: Intervention (n = 80) that received sodium hydrosulfide (NaHS, 14 μmoL/kg·d) intervention after ROSC; Inhibition (n = 80) that received hydroxylamine (40 μmoL/kg·d) intervention after ROSC; and Control (n = 80) that received saline after ROSC. Kaplan-Meyer analysis was used to analyze the survival data. Quantitative real-time PCR (q-PCR), Western blot, immunohistochemistry and IODs (integrated optical density) were performed to determine the mRNA and protein expressions of BDNF, TrkB and p75NTR in rat brain tissues.

resultsSurvival rate of the three groups had significant difference (χ

conclusionNaHS treatment increases the survival rate of rats after CA and ROSC by upregulating the expression and activation of BDNF and its receptor TrkB, and down-regulating p75NTR expression.

Indexed as

Heart Arrest, InducedAnimalsBrain-Derived Neurotrophic FactorCardiopulmonary ResuscitationDown-RegulationHydrogen SulfideHydroxylamineMembrane GlycoproteinsModels, AnimalNerve Tissue ProteinsNeuroprotective AgentsRats, Sprague-DawleyReceptors, Growth FactorReceptors, Nerve Growth FactorReceptor, trkBRNA, MessengerBrain-Derived Neurotrophic FactorHydrogen SulfideHydroxylamineMembrane GlycoproteinsNerve Tissue ProteinsNeuroprotective AgentsNgfr protein, ratReceptors, Growth FactorReceptors, Nerve Growth FactorReceptor, trkBRNA, Messengertropomyosin-related kinase-B, humanBrain-derived neurotrophic factorHydrogen sulfidep75 neurotrophin receptorTyrosine protein kinase B

Identifiers

PMID30577733
PMCPMC6303943
OpenAlexW2906436012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.