Evidence map›Paper›PMID 30577475›Full record

ReviewMolecules (Basel, Switzerland)2018

Recent Development of pH-Responsive Polymers for Cancer Nanomedicine.

Houliang Tang, Weilong Zhao, Jinming Yu, Yang Li, Chao Zhao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  4. Review
  5. Polymeric Nanocarriers with pH-Dependent Release for Tumor-Specific Delivery.Recent advances in drug delivery and formulation · 2026
    Review
  6. Article
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  11. Enhancing immunotherapy with tumour-responsive nanomaterials.Nature reviews. Clinical oncology · 2025
    Review
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  16. Article
  17. Article
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Houliang TangDepartment of Chemistry, Southern Methodist University, 3215 Daniel Avenue, Dallas, TX 75275, USA. houliangt@smu.edu.ORCID 0000-0003-2137-8507
Weilong ZhaoGlobal Research IT, Merck & Co., Inc., Boston, MA 02210, USA. weilong.zhao@merck.com.
Jinming YuDepartment of Chemical and Biological Engineering, the University of Alabama, Tuscaloosa, AL 35487, USA. jyu56@crimson.ua.edu.
Yang LiBoston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. Yang.Li2@childrens.harvard.edu.
Chao ZhaoDepartment of Chemical and Biological Engineering, the University of Alabama, Tuscaloosa, AL 35487, USA. czhao15@eng.ua.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer remains a leading cause of death worldwide with more than 10 million new cases every year. Tumor-targeted nanomedicines have shown substantial improvements of the therapeutic index of anticancer agents, addressing the deficiencies of conventional chemotherapy, and have had a tremendous growth over past several decades. Due to the pathophysiological characteristics that almost all tumor tissues have lower pH in comparison to normal healthy tissues, among various tumor-targeted nanomaterials, pH-responsive polymeric materials have been one of the most prevalent approaches for cancer diagnosis and treatment. In this review, we summarized the types of pH-responsive polymers, describing their chemical structures and pH-response mechanisms; we illustrated the structure-property relationships of pH-responsive polymers and introduced the approaches to regulating their pH-responsive behaviors; we also highlighted the most representative applications of pH-responsive polymers in cancer imaging and therapy. This review article aims to provide general guidelines for the rational design of more effective pH-responsive nanomaterials for cancer diagnosis and treatment.

Indexed as

HumansHydrogen-Ion ConcentrationNanomedicineNeoplasmsPolymersPolymersdrug deliverynanomedicinepH responsive polymerstumor imaging

Identifiers

PMID30577475
PMCPMC6337262

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.