ArticleNutrients2018
Maternal Overnutrition Induces Long-Term Cognitive Deficits across Several Generations.
Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Neurodevelopmental Pathways from Maternal Obesity to Offspring Outcomes: An Umbrella Review of Cognitive and Behavioral Consequences Across Development.Healthcare (Basel, Switzerland) · 2025Review
- Does the Maternal Gut Microbiome Influence the Outcome of Perinatal Asphyxia?Antioxidants (Basel, Switzerland) · 2025Review
- Autism Spectrum Disorder: From Experimental Models to Probiotic Application with a Special Focus onNutrients · 2025Review
- Programming the Brain: How Maternal Overnutrition Shapes Cognitive Aging in Offspring.Nutrients · 2025Article
- Maternal gut microbiota in the health of mothers and offspring: from the perspective of immunology.Frontiers in immunology · 2024Review
- Maternal Over- and Malnutrition and Increased Risk for Addictive and Eating Disorders in the Offspring.Nutrients · 2023Review
- The Influence of Maternal Metabolic State and Nutrition on Offspring Neurobehavioral Development: A Focus on Preclinical Models.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Review
- Transgenerational effects of grandparental and parental diets combine with early-life learning to shape adaptive foraging phenotypes in Amblyseius swirskii.Communications biology · 2022Article
- Overnutrition Induced Cognitive Impairment: Insulin Resistance, Gut-Brain Axis, and Neuroinflammation.Frontiers in neuroscience · 2022Review
- Microbiomics: The Next Pillar of Precision Medicine and Its Role in African Healthcare.Frontiers in genetics · 2022Article
- Intrauterine hyperglycemia impairs memory across two generations.Translational psychiatry · 2021Article
- Effects of Gestational Diabetes in Cognitive Behavior, Oxidative Stress and Metabolism on the Second-Generation Off-Spring of Rats.Nutrients · 2021Article
- The Microbiota-Gut-Brain Axis in Health and Disease and Its Implications for Translational Research.Frontiers in cellular neuroscience · 2021Review
- Understanding the Link Between Maternal Overnutrition, Cardio-Metabolic Dysfunction and Cognitive Aging.Frontiers in neuroscience · 2021Review
- Article
- The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology.Frontiers in immunology · 2020Review
- Environmental and Nutritional Effects Regulating Adipose Tissue Function and Metabolism Across Generations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Review
- Maternal Consumption of a Diet Rich in Maillard Reaction Products Accelerates Neurodevelopment in F1 and Sex-Dependently Affects Behavioral Phenotype in F2 Rat Offspring.Foods (Basel, Switzerland) · 2019Article
- Pre- and Post-natal High Fat Feeding Differentially Affects the Structure and Integrity of the Neurovascular Unit of 16-Month Old Male and Female Mice.Frontiers in neuroscience · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ample evidence from epidemiological studies has linked maternal obesity with metabolic disorders such as obesity, cardiovascular disease, and diabetes in the next generation. Recently, it was also shown that maternal obesity has long-term effects on the progeny's central nervous system. However, very little is known regarding how maternal overnutrition may affect, in particular, the cognitive abilities of the offspring. We reported that first-generation offspring exposed to a maternal high-fat diet (MHFD) displayed age-dependent cognitive deficits. These deficits were associated with attenuations of amino acid levels in the medial prefrontal cortex and the hippocampus regions of MHFD offspring. Here, we tested the hypothesis that MHFD in mice may induce long-term cognitive impairments and neurochemical dysfunctions in the second and third generations. We found that MHFD led to cognitive disabilities and an altered response to a noncompetitive receptor antagonist of the N-Methyl-D-aspartic acid (NMDA) receptor in adult MHFD offspring in both second and third generations in a sex-specific manner. Our results suggest that maternal overnutrition leads to an increased risk of developing obesity in subsequent generations as well as to cognitive impairments, affecting learning and memory processes in adulthood. Furthermore, MHFD exposure may facilitate pathological brain aging which is not a consequence of obesity. Our findings shed light on the long-term effects of maternal overnutrition on the development of the central nervous system and the underlying mechanisms which these traits relate to disease predisposition.
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