ArticleRedox biology2019
Inhibition of thioredoxin-dependent H
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In one paragraph
Article in Redox biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Assessing Auranofin for Second-Line Use in Chemoresistant Ovarian Cancer: Effects on Tumour Spheroid and Primary Cell Growth.Journal of cellular and molecular medicine · 2025Article
- Mitochondrial quality control as a therapeutic target in cardiovascular disease: Mechanistic insights and future directions.Journal of translational internal medicine · 2025Article
- Pharmacological Vitamin C-induced high HJournal of translational medicine · 2025Article
- Apoliprotein E-mediated ferroptosis controls cellular proliferation in chronic lymphocytic leukemia.Leukemia · 2025Article
- Analysis of High-Dose Ascorbate-Induced Cytotoxicity in Human Glioblastoma Cells and the Role of Dehydroascorbic Acid and Iron.Antioxidants (Basel, Switzerland) · 2024Article
- Exploring the Thioredoxin System as a Therapeutic Target in Cancer: Mechanisms and Implications.Antioxidants (Basel, Switzerland) · 2024Review
- Robust and cost-effective CRISPR/Cas9 gene editing of primary tumor B cells in Eµ-TCL1 model of chronic lymphocytic leukemia.HemaSphere · 2024Article
- Article
- Auranofin Induces Lethality Driven by Reactive Oxygen Species in High-Grade Serous Ovarian Cancer Cells.Cancers · 2023Article
- Oxidative Stress and Inflammation in B-Cell Lymphomas.Antioxidants (Basel, Switzerland) · 2023Review
- Possible Mechanisms of Resistance Development to Photodynamic Therapy (PDT) In Vulvar Cancer Cells.International journal of molecular sciences · 2022Article
- Auranofin and Pharmacologic Ascorbate as Radiomodulators in the Treatment of Pancreatic Cancer.Antioxidants (Basel, Switzerland) · 2022Review
- Upgrade of an old drug: Auranofin in innovative cancer therapies to overcome drug resistance and to increase drug effectiveness.Medicinal research reviews · 2022Review
- PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress.Cancer immunology research · 2022Article
- High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer.Journal of experimental & clinical cancer research : CR · 2021Review
- The gold complex auranofin: new perspectives for cancer therapy.Discover oncology · 2021Review
- Multiple Effects of Ascorbic Acid against Chronic Diseases: Updated Evidence from Preclinical and Clinical Studies.Antioxidants (Basel, Switzerland) · 2020Review
- Ascorbic acid (vitamin C) synergistically enhances the therapeutic effect of targeted therapy in chronic lymphocytic leukemia.Journal of experimental & clinical cancer research : CR · 2020Article
- Mitochondrial quality control mechanisms as molecular targets in cardiac ischemiaActa pharmaceutica Sinica. B · 2020Review
- Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells.Antioxidants (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
25 authors at 4 institutions in 2 countries.
Agnieszka Graczyk-JarzynkaDepartment of Immunology, Medical University of Warsaw, Nielubowicza 5 Street, 02-097 Warsaw, Poland. Electronic address: agnieszka.graczyk-jarzynka@wum.edu.pl.
Agnieszka GoralDepartment of Immunology, Medical University of Warsaw, Nielubowicza 5 Street, 02-097 Warsaw, Poland. Electronic address: agnieszka.goral@wum.edu.pl.
Angelika MuchowiczDepartment of Immunology, Medical University of Warsaw, Nielubowicza 5 Street, 02-097 Warsaw, Poland. Electronic address: angelika.muchowicz@wum.edu.pl.
Radoslaw ZagozdzonDepartment of Immunology, Medical University of Warsaw, Nielubowicza 5 Street, 02-097 Warsaw, Poland; Department of Clinical Immunology, Transplantation Institute, Medical University of Warsaw, Nowogrodzka 59 Street, 02-006 Warsaw, Poland; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5 A Street, 02-106 Warsaw, Poland. Electronic address: radoslaw.zagozdzon@wum.edu.pl.
Magdalena WiniarskaDepartment of Immunology, Medical University of Warsaw, Nielubowicza 5 Street, 02-097 Warsaw, Poland. Electronic address: mwiniarska@wum.edu.pl.
Malgorzata BajorDepartment of Immunology, Medical University of Warsaw, Nielubowicza 5 Street, 02-097 Warsaw, Poland. Electronic address: malgorzata.bajor@wum.edu.pl.
Anna TrzecieckaDepartment of Immunology, Medical University of Warsaw, Nielubowicza 5 Street, 02-097 Warsaw, Poland.
Klaudyna FidytDepartment of Immunology, Medical University of Warsaw, Nielubowicza 5 Street, 02-097 Warsaw, Poland; Postgraduate School of Molecular Medicine, Medical University of Warsaw, Zwirki i Wigury 61 Street, 02-091 Warsaw, Poland. Electronic address: klaudyna.fidyt@wum.edu.pl.
Joanna Alicja KrupkaDepartment of Immunology, Medical University of Warsaw, Nielubowicza 5 Street, 02-097 Warsaw, Poland.
Julia CyranDepartment of Immunology, Medical University of Warsaw, Nielubowicza 5 Street, 02-097 Warsaw, Poland. Electronic address: js.cyran@student.uw.edu.pl.
Kacper SzczygielDepartment of Immunology, Medical University of Warsaw, Nielubowicza 5 Street, 02-097 Warsaw, Poland.
Dimitar G EfremovMolecular Hematology, International Centre for Genetic Engineering & Biotechnology, Località Padriciano 99 Street, 34149 Trieste, Italy. Electronic address: Dimitar.Efremov@icgeb.org.
Stefania GobessiMolecular Hematology, International Centre for Genetic Engineering & Biotechnology, Località Padriciano 99 Street, 34149 Trieste, Italy.
Adam JagielskiDepartment of Metabolic Regulation, Institute of Biochemistry, Faculty of Biology, University of Warsaw, Miecznikowa 1 Street, 02-096 Warsaw, Poland.
Karolina SiudakowskaDepartment of Immunology, Medical University of Warsaw, Nielubowicza 5 Street, 02-097 Warsaw, Poland. Electronic address: karolina.siudakowska@wum.edu.pl.
Malgorzata BobrowiczDepartment of Immunology, Medical University of Warsaw, Nielubowicza 5 Street, 02-097 Warsaw, Poland. Electronic address: malgorzata.bobrowicz@wum.edu.pl.
Marta KlopotowskaDepartment of Immunology, Medical University of Warsaw, Nielubowicza 5 Street, 02-097 Warsaw, Poland; Postgraduate School of Molecular Medicine, Medical University of Warsaw, Zwirki i Wigury 61 Street, 02-091 Warsaw, Poland. Electronic address: marta.klopotowska@wum.edu.pl.
Joanna BarankiewiczDepartment of Hematology, Institute of Hematology and Transfusion Medicine, Gandhi 14 Street, 02-776 Warsaw, Poland; Department of Hematology and Transfusion Medicine, Centre of Postgraduate Medicine, Marymoncka 99/103 Street, 01-813 Warsaw, Poland.
Agata MalendaDepartment of Hematology, Institute of Hematology and Transfusion Medicine, Gandhi 14 Street, 02-776 Warsaw, Poland.
Ewa Lech-MarandaDepartment of Hematology, Institute of Hematology and Transfusion Medicine, Gandhi 14 Street, 02-776 Warsaw, Poland; Department of Hematology and Transfusion Medicine, Centre of Postgraduate Medicine, Marymoncka 99/103 Street, 01-813 Warsaw, Poland. Electronic address: ewamaranda@wp.pl.
Nina Miazek-ZapalaDepartment of Immunology, Medical University of Warsaw, Nielubowicza 5 Street, 02-097 Warsaw, Poland; Institute of Physiology and Pathology of Hearing, World Hearing Center, Mochnackiego 10 Street, 02-042 Warsaw, Poland.
Piotr Henryk SkarzynskiInstitute of Physiology and Pathology of Hearing, World Hearing Center, Mochnackiego 10 Street, 02-042 Warsaw, Poland; Institute of Sensory Organs, Mokra 17 Street, 05-830 Kajetany, Poland; Department of Heart Failure and Cardiac Rehabilitation, Medical University of Warsaw, Kondratowicza 8 Street, 03-242 Warsaw, Poland.
Antoni DomagalaDepartment of Immunology, Medical University of Warsaw, Nielubowicza 5 Street, 02-097 Warsaw, Poland.
Jakub GolabDepartment of Immunology, Medical University of Warsaw, Nielubowicza 5 Street, 02-097 Warsaw, Poland; Centre for Preclinical Research and Technology, Medical University of Warsaw, Zwirki I Wigury 81 Street, 02-091 Warsaw, Poland. Electronic address: jakub.golab@wum.edu.pl.
Malgorzata FirczukDepartment of Immunology, Medical University of Warsaw, Nielubowicza 5 Street, 02-097 Warsaw, Poland. Electronic address: mfirczuk@wum.edu.pl.
Medical University of Warsaw · PLInstytut Hematologii i Transfuzjologi · PLInternational Centre for Genetic Engineering and Biotechnology · ITUniversity of Warsaw · PL
Funding
No grant is acknowledged in the PubMed record.
Abstract
L-ascorbate (L-ASC) is a widely-known dietary nutrient which holds promising potential in cancer therapy when given parenterally at high doses. The anticancer effects of L-ASC involve its autoxidation and generation of H
Indexed as
AnimalsAscorbic AcidB-LymphocytesCell LineCell Line, TumorDisease Models, AnimalDrug Resistance, NeoplasmHumansHydrogen PeroxideIronLeukemia, B-CellLymphoma, B-CellMiceThioredoxinsXenograft Model Antitumor AssaysAscorbic AcidHydrogen PeroxideIronThioredoxins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.