Evidence map›Paper›PMID 30576660›Full record

ArticleCell chemical biology2018

A BAF'ling Approach to Curing HIV.

Sakshi Tomar, Ibraheem Ali, Melanie Ott

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Targeting HIV-1 proviral transcription.Current opinion in virology · 2019
    Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Sakshi TomarJ. David Gladstone Institutes, 1650 Owens Street, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.
Ibraheem AliJ. David Gladstone Institutes, 1650 Owens Street, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.
Melanie OttJ. David Gladstone Institutes, 1650 Owens Street, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA. Electronic address: mott@gladstone.ucsf.edu.

Funding

MOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0M
A new model of accelerated immune aging in HIV-infected drug usersDP1DA038043 · NIDA · J. DAVID GLADSTONE INSTITUTES · PI OTT, MELANIE MARIA · 2014 to 2019
$4.8M
Role of Factor Acetylation in the Regulation of HIV TranscriptionR01AI083139 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI OTT, MELANIE MARIA · 2009 to 2017
$3.9M
Targeting lysine methylation for latency reversal in HIV-infected drug usersR01DA043142 · NIDA · J. DAVID GLADSTONE INSTITUTES · PI OTT, MELANIE MARIA · 2016 to 2020
$3.0M
NIAID NIH HHS R01 AI083139NIAID NIH HHS T32 AI007334NIDA NIH HHS DP1 DA038043NIDA NIH HHS R01 DA043142
6 · The paper itself

Abstract

Latency is the primary barrier to the development of a long-sought cure for HIV-1. In this issue of Cell Chemical Biology, Marian et al., (2018) describe the development of novel compounds targeting the BAF chromatin remodeling complex to reverse HIV latency, with the potential to provide a functional cure.

Indexed as

HIV-1Virus LatencyTranscription FactorsTranscription Factors

Identifiers

PMID30576660
PMCPMC6582950

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.