ArticleThe Journal of infectious diseases2019
An Intensive, Active Surveillance Reveals Continuous Invasion and High Diversity of Rhinovirus in Households.
Article in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- rhinotypeR enables reproducible rhinovirus genotype assignment from VP4/2 sequences.Scientific reports · 2026Article
- Spatio-temporal distribution of rhinovirus types in Kenya: a retrospective analysis, 2014.Scientific reports · 2024Article
- Article
- Rhinovirus dynamics across different social structures.Npj viruses · 2023Article
- Molecular Epidemiology of Rhinovirus/Enterovirus and Their Role on Cause Severe and Prolonged Infection in Hospitalized Patients.Microorganisms · 2022Article
- Identification of missed viruses by metagenomic sequencing of clinical respiratory samples from Kenya.Scientific reports · 2022Article
- Trends and Intensity of Rhinovirus Invasions in Kilifi, Coastal Kenya, Over a 12-Year Period, 2007-2018.Open forum infectious diseases · 2021Article
- Review
- High burden of viral respiratory co-infections in a cohort of children with suspected pulmonary tuberculosis.BMC infectious diseases · 2020Observational
- Molecular Epidemiology of Human Rhinovirus From 1-Year Surveillance Within a School Setting in Rural Coastal Kenya.Open forum infectious diseases · 2020Article
- Risk factors and patterns of household clusters of respiratory viruses in rural Nepal.Epidemiology and infection · 2019Article
- An Intensive, Active Surveillance Reveals Continuous Invasion and High Diversity of Rhinovirus in Households.The Journal of infectious diseases · 2019Article
- Human rhinovirus spatial-temporal epidemiology in rural coastal Kenya, 2015-2016, observed through outpatient surveillance.Wellcome open research · 2018Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
We report on infection patterns in 5 households (78 participants) delineating the natural history of human rhinovirus (HRV). Nasopharyngeal collections were obtained every 3-4 days irrespective of symptoms, over a 6-month period, with molecular screening for HRV and typing by sequencing VP4/VP2 junction. Overall, 311/3468 (8.9%) collections were HRV positive: 256 were classified into 3 species: 104 (40.6%) HRV-A; 14 (5.5%) HRV-B, and 138 (53.9%) HRV-C. Twenty-six known HRV types (13 HRV-A, 3 HRV-B, and 10 HRV-C) were identified (A75, C1, and C35 being most frequent). We observed continuous invasion and temporal clustering of HRV types in households (range 5-13 over 6 months). Intrahousehold transmission was independent of clinical status but influenced by age. Most (89.0%) of HRV infection episodes were limited to <14 days. Individual repeat infections were frequent (range 1-7 over 6 months), decreasing with age, and almost invariably heterotypic, indicative of lasting type-specific immunity and low cross-type protection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.