ArticleMolecular biology and evolution2019
Degenerative Expansion of a Young Supergene.
Article in Molecular biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Genome Evolution in Social Insects.Genome biology and evolution · 2026Review
- Molecular Evolution of a Sex-Linked Inversion Polymorphism in Zebra Finches.Genome biology and evolution · 2026Article
- Ancient but dynamic: structural expansion, massive gene duplication, and transposable element colonization in a supergene controlling ant social organization.Molecular biology and evolution · 2026Article
- Sexes Are Polymorphisms: Describing and Understanding Sexual Diversity as Phenotypic Variation.Integrative and comparative biology · 2026Review
- Distinct haplotypes and reversed dominance at a single-gene balanced polymorphism controlling heterodichogamy in two genera of wingnuts.Current biology : CB · 2025Article
- The Fire Ant Social Chromosome Exerts a Major Influence on Genome Regulation.Molecular biology and evolution · 2025Article
- Biased social chromosome transmission in males of the fire ant Solenopsis invicta.G3 (Bethesda, Md.) · 2025Article
- Social antagonism facilitates supergene expansion in ants.Current biology : CB · 2023Article
- Low Mutation Load in a Supergene Underpinning Alternative Male Mating Strategies in Ruff (Calidris pugnax).Molecular biology and evolution · 2023Article
- A supergene in seaweed flies modulates male traits and female perception.Proceedings. Biological sciences · 2023Article
- Radiation and hybridization underpin the spread of the fire ant social supergene.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Iterative evolution of supergene-based social polymorphism in ants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- A socially polymorphic Formica ant species exhibits a novel distribution of social supergene genotypes.Journal of evolutionary biology · 2022Article
- Supergenes on steroids.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Individual-based Modeling of Genome Evolution in Haplodiploid Organisms.Genome biology and evolution · 2022Article
- Epistatic selection on a selfisheLife · 2022Article
- Tempo of Degeneration Across Independently Evolved Nonrecombining Regions.Molecular biology and evolution · 2022Article
- Intralocus conflicts associated with a supergene.Nature communications · 2022Article
- Recurring adaptive introgression of a supergene variant that determines social organization.Nature communications · 2022Article
- Novel patterns of expression and recruitment of new genes on theProceedings. Biological sciences · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term suppression of recombination ultimately leads to gene loss, as demonstrated by the depauperate Y and W chromosomes of long-established pairs of XY and ZW chromosomes. The young social supergene of the Solenopsis invicta red fire ant provides a powerful system to examine the effects of suppressed recombination over a shorter timescale. The two variants of this supergene are carried by a pair of heteromorphic chromosomes, referred to as the social B and social b (SB and Sb) chromosomes. The Sb variant of this supergene changes colony social organization and has an inheritance pattern similar to a Y or W chromosome because it is unable to recombine. We used high-resolution optical mapping, k-mer distribution analysis, and quantification of repetitive elements on haploid ants carrying alternate variants of this young supergene region. We find that instead of shrinking, the Sb variant of the supergene has increased in length by more than 30%. Surprisingly, only a portion of this length increase is due to consistent increases in the frequency of particular classes of repetitive elements. Instead, haplotypes of this supergene variant differ dramatically in the amounts of other repetitive elements, indicating that the accumulation of repetitive elements is a heterogeneous and dynamic process. This is the first comprehensive demonstration of degenerative expansion in an animal and shows that it occurs through nonlinear processes during the early evolution of a region of suppressed recombination.
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