Evidence map›Paper›PMID 30576377›Full record

ArticlePloS one2018

Maternal dyslipidemia and risk for preterm birth.

Caitlin J Smith, Rebecca J Baer, Scott P Oltman, Patrick J Breheny, Wei Bao, Jennifer G Robinson, John M Dagle, Liang Liang, Sky K Feuer, Christina D Chambers and 2 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Lipid and Glucose Profiles in Pregnant Women With HIV on Tenofovir-based Antiretroviral Therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Trial
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  14. A Scoping Review of Preterm Birth Risk Factors.American journal of perinatology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Caitlin J SmithDepartment of Epidemiology, University of Iowa, Iowa City, Iowa, United States of America.
Rebecca J BaerDepartment of Pediatrics, University of California San Diego, La Jolla, California, United States of America.
Scott P OltmanCalifornia Preterm Birth Initiative, University of California San Francisco, San Francisco, California, United States of America.
Patrick J BrehenyDepartment of Biostatistics, University of Iowa, Iowa City, Iowa, United States of America.ORCID 0000-0002-0650-1119
Wei BaoDepartment of Epidemiology, University of Iowa, Iowa City, Iowa, United States of America.
Jennifer G RobinsonDepartment of Epidemiology, University of Iowa, Iowa City, Iowa, United States of America.
John M DagleDepartment of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America.
Liang LiangDepartment of Genetics, Stanford University, Stanford, California, United States of America.
Sky K FeuerDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California San Francisco, San Francisco, California, United States of America.
Christina D ChambersDepartment of Pediatrics, University of California San Diego, La Jolla, California, United States of America.
Laura L Jelliffe-PawlowskiCalifornia Preterm Birth Initiative, University of California San Francisco, San Francisco, California, United States of America.
Kelli K RyckmanDepartment of Epidemiology, University of Iowa, Iowa City, Iowa, United States of America.ORCID 0000-0002-9496-4147
University of Iowa · USUniversity of California, San Francisco · USStanford University · USUniversity of California San Diego · US

Funding

Rheumatic Diseases Research Training GrantT32AR064194 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARY S FIRESTEIN, Monica Guma · 2013 to 2026
$3.8M
NIAMS NIH HHS T32 AR064194
6 · The paper itself

Abstract

Maternal lipid profiles during pregnancy are associated with risk for preterm birth. This study investigates the association between maternal dyslipidemia and subsequent preterm birth among pregnant women in the state of California. Births were identified from California birth certificate and hospital discharge records from 2007-2012 (N = 2,865,987). Preterm birth was defined as <37 weeks completed gestation and dyslipidemia was defined by diagnostic codes. Subtypes of preterm birth were classified as preterm premature rupture of membranes (PPROM), spontaneous labor, and medically indicated, according to birth certificate data and diagnostic codes. The association between dyslipidemia and preterm birth was tested with logistic regression. Models were adjusted for maternal age at delivery, race/ethnicity, hypertension, pre-pregnancy body mass index, insurance type, and education. Maternal dyslipidemia was significantly associated with increased odds of preterm birth (adjusted OR: 1.49, 95%CI: 1.39, 1.59). This finding was consistent across all subtypes of preterm birth, including PPROM (adjusted OR: 1.54, 95%CI: 1.34, 1.76), spontaneous (adjusted OR: 1.51, 95%CI: 1.39, 1.65), and medically indicated (adjusted OR: 1.454, 95%CI: 1.282, 1.649). This study suggests that maternal dyslipidemia is associated with increased risk for all types of preterm birth.

Indexed as

AdultBody Mass IndexDyslipidemiasFemaleGestational AgeHumansHypertensionInfant, NewbornLipidsLogistic ModelsMaternal AgePregnancyPregnancy Complications, CardiovascularPremature BirthPremature Rupture of Fetal MembranesRisk FactorsLipids

Identifiers

PMID30576377
PMCPMC6303099
OpenAlexW2905685521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.