ArticlePloS one2018
Measurement of liver iron by magnetic resonance imaging in the UK Biobank population.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Coffee Consumption and Improved Liver Outcomes: Clinical, Imaging, and Proteomic Evidence From the UK Biobank.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026Article
- Intrinsic capacity, genetic susceptibility, and the risks of metabolic dysfunction-associated steatotic liver disease and cirrhosis.International journal of surgery (London, England) · 2026Article
- Fat Fraction and Iron Concentration in Lumbar Vertebral Bone Marrow in the UK Biobank.Obesity science & practice · 2025Article
- State-of-the-Art Quantification of Liver Iron With MRI-Vendor Implementation and Available Tools.Journal of magnetic resonance imaging : JMRI · 2025Review
- A Protocol for Body MRI/CT and Extraction of Imaging-Derived Phenotypes (IDPs) from the China Phenobank Project.Phenomics (Cham, Switzerland) · 2024Article
- Multi-organ imaging-derived polygenic indexes for brain and body health.medRxiv : the preprint server for health sciences · 2024Article
- Prospective study design and data analysis in UK Biobank.Science translational medicine · 2024Review
- Multi-organ imaging demonstrates the heart-brain-liver axis in UK Biobank participants.Nature communications · 2022Article
- Multiomics study of nonalcoholic fatty liver disease.Nature genetics · 2022Article
- Article
- Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analyses.PLoS medicine · 2022Observational
- Analysis of MRI-derived spleen iron in the UK Biobank identifies genetic variation linked to iron homeostasis and hemolysis.American journal of human genetics · 2022Article
- Greater ectopic fat deposition and liver fibroinflammation and lower skeletal muscle mass in people with type 2 diabetes.Obesity (Silver Spring, Md.) · 2022Article
- Quantitative MR in Paediatric Patients with Wilson Disease: A Case Series Review.Children (Basel, Switzerland) · 2022Article
- Precision MRI phenotyping enables detection of small changes in body composition for longitudinal cohorts.Scientific reports · 2022Article
- Association of Habitual Dietary Intake with Liver Iron-A Population-Based Imaging Study.Nutrients · 2021Article
- Distribution and Associated Factors of Hepatic Iron-A Population-Based Imaging Study.Metabolites · 2021Article
- Article
- Dietary intake of specific amino acids and liver status in subjects with nonalcoholic fatty liver disease: fatty liver in obesity (FLiO) study.European journal of nutrition · 2021Article
- Multiparametric MRI in Patients With Nonalcoholic Fatty Liver Disease.Journal of magnetic resonance imaging : JMRI · 2021Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The burden of liver disease continues to increase in the UK, with liver cirrhosis reported to be the third most common cause of premature death. Iron overload, a condition that impacts liver health, was traditionally associated with genetic disorders such as hereditary haemochromatosis, however, it is now increasingly associated with obesity, type-2 diabetes and non-alcoholic fatty liver disease. The aim of this study was to assess the prevalence of elevated levels of liver iron within the UK Biobank imaging study in a cohort of 9108 individuals. Magnetic resonance imaging (MRI) was undertaken at the UK Biobank imaging centre, acquiring a multi-echo spoiled gradient-echo single-breath-hold MRI sequence from the liver. All images were analysed for liver iron and fat (expressed as proton density fat fraction or PDFF) content using LiverMultiScan. Liver iron was measured in 97.3% of the cohort. The mean liver iron content was 1.32 ± 0.32 mg/g while the median was 1.25 mg/g (min: 0.85 max: 6.44 mg/g). Overall 4.82% of the population were defined as having elevated liver iron, above commonly accepted 1.8 mg/g threshold based on biochemical iron measurements in liver specimens obtained by biopsy. Further analysis using univariate models showed elevated liver iron to be related to male sex (p<10(-16), r2 = 0.008), increasing age (p<10(-16), r2 = 0.013), and red meat intake (p<10(-16), r2 = 0.008). Elevated liver fat (>5.6% PDFF) was associated with a slight increase in prevalence of elevated liver iron (4.4% vs 6.3%, p = 0.0007). This study shows that population studies including measurement of liver iron concentration are feasible, which may in future be used to better inform patient stratification and treatment.
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