ReviewEuropean journal of endocrinology2019
MECHANISMS IN ENDOCRINOLOGY: Endocrine and immunological aspects of burnout: a narrative review.
Review in European journal of endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Biological Markers of Burnout Severity: A Systematic Review.Stress and health : journal of the International Society for the Investigation of Stress · 2026Pooled it
- Chronic stress in relation to clinical burnout: an integrative scoping review of definitions and measurement approaches.Frontiers in psychology · 2025Pooled it
- Terpenes as Potential Multi-Target Modulators of Chronic Stress-Induced Neuroendocrine-Immune Dysregulation.International journal of molecular sciences · 2026Review
- Self-compassion as a well-being strategy against burnout among dentists: a controlled intervention study.BMC psychology · 2026Article
- Burnout and Biological Biomarkers in Emergency and Acute-Care Healthcare Workers: A Systematic Scoping Review with Evidence Mapping.Medicina (Kaunas, Lithuania) · 2026Article
- Effect of chronic stress on human endocrine function: A biomarker-based study.Bioinformation · 2026Article
- The Biological Clock Influenced by Burnout, Hormonal Dysregulation and Circadian Misalignment: A Systematic Review.Clocks & sleep · 2025Review
- The role of burnout prevention in promoting healthy aging: frameworks for the Semmelweis Study and Semmelweis-EUniWell Workplace Health Promotion Program.GeroScience · 2025Review
- Work-related stress and burnout: Is epigenetic aging the missing link?Clinical epigenetics · 2025Article
- Burnout Syndrome Among Dental Students in Clinical Training: A Multicenter Cross-Sectional Study in Ecuador.International journal of environmental research and public health · 2025Article
- Reduced interleukin-6 stress reactivity in male physicians with occupational burnout.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Blood Metabolic Biomarkers of Occupational Stress in Healthcare Professionals: Discriminating Burnout Levels and the Impact of Night Shift Work.Clocks & sleep · 2025Article
- Psilocybin mitigates behavioral despair and cognitive impairment in treatment-resistant depression model using wistar kyoto rats.Scientific reports · 2025Article
- Urine Metabolomic Patterns to Discriminate the Burnout Levels and Night-Shift-Related Stress in Healthcare Professionals.Metabolites · 2025Article
- Relationship between burnout and serum markers in military personnel in plateau and plain areas of China: a cross-sectional study.Frontiers in public health · 2025Article
- A Narrative Review of Burnout Syndrome in Medical Personnel.Diagnostics (Basel, Switzerland) · 2024Review
- Severe Itch Related to Hard Workload Treated with Acupuncture: Unexpected Results - A Case report.Complementary medicine research · 2024Article
- Association between omega-3 index and depersonalization among healthcare workers in a university hospital: a cross-sectional study.Frontiers in psychiatry · 2024Article
- Associations of psychological status and ultrasonic characteristics of thyroid nodules in adults during the COVID-19 pandemic.Frontiers in psychology · 2023Article
- Sustained seropositivity up to 20.5 months after COVID-19.BMC medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Burnout has several different definitions, and attempts have been made to discriminate between burnout as a psychological construct and burnout as a clinical entity. A large body of research has focused on elucidating the biological link between stress exposure and burnout and/or finding a clinically usable biomarker for burnout. The objective of this narrative review is to summarize the main endocrine and immune findings in relation to burnout. The literature has primarily focused on dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis. However, albeit the large body of studies, it cannot be concluded that clear effects are seen on HPA axis function in people with burnout. The HPA axis and anabolic acute reactivity to stress might be affected in clinical burnout. Plausible, effects of chronic stress might rather be seen when measuring responses to acute stress rather than resting state hormonal levels. Studies on other hormones, including thyroid hormones, prolactin and growth hormone in burnout subjects are inconclusive. It is important to note that this field is faced with many methodological challenges, one being the diurnal and pulsatile nature of many of the hormones of interest, including cortisol, which is not always considered. Another challenge is the heterogeneity regarding definitions and measurements of stress and burnout. Existing studies on burnout and immune function are heterogeneous regarding the results and no firm conclusion can be made if clinically relevant immune changes are present in burnout subjects. An overall conclusion is that existing research cannot confirm any homogenous reliable endocrinological or immunological changes related to burnout.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.