Evidence map›Paper›PMID 30576237›Full record

ArticleAmerican journal of physiology. Cell physiology2019

Genetic and pharmacological inactivation of apical Na

Jeannine M C Gregoriades, Aaron Madaris, Francisco J Alvarez, Francisco J Alvarez-Leefmans

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 81 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Molecular hallmarks of hydrocephalus.Science translational medicine · 2025
    Review
  6. Article
  7. Review
  8. Review
  9. Mechanisms of hydrocephalus after intraventricular haemorrhage: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Consideration of Kinase Inhibitors for the Treatment of Hydrocephalus.International journal of molecular sciences · 2023
    Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jeannine M C GregoriadesDepartment of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University , Dayton, Ohio.
Aaron MadarisDepartment of Biomedical, Industrial, and Human Factors Engineering, College of Engineering and Computer Science, Wright State University , Dayton, Ohio.
Francisco J AlvarezDepartment of Neuroscience, Cell Biology and Physiology, Wright State University , Dayton, Ohio.
Francisco J Alvarez-LeefmansDepartment of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University , Dayton, Ohio.ORCID 0000-0003-4011-3846
Wright State University · US

Funding

Cell Volume Regulation in Neurons and GliaR01NS029227 · NINDS · WRIGHT STATE UNIVERSITY · PI ALVAREZ-LEEFMANS, FRANCISCO J · 1991 to 2006
$1.5M
NINDS NIH HHS R01 NS029227
6 · The paper itself

Abstract

Choroid plexus epithelial cells (CPECs) secrete cerebrospinal fluid (CSF). They express Na

Indexed as

AnimalsBumetanideCells, CulturedChoroid PlexusEpithelial CellsMiceMice, 129 StrainMice, Inbred C57BLSodium Potassium Chloride Symporter InhibitorsSolute Carrier Family 12, Member 2BumetanideSlc12a2 protein, mouseSodium Potassium Chloride Symporter InhibitorsSolute Carrier Family 12, Member 2apical NKCC1cell volumechoroid plexus epithelial cellsNKCC1−/−ultrastructure

Identifiers

PMID30576237
PMCPMC6482671
OpenAlexW2906154139

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.