Evidence map›Paper›PMID 30576225›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Hepatocyte and stellate cell deletion of liver fatty acid binding protein reveals distinct roles in fibrogenic injury.

Elizabeth P Newberry, Yan Xie, Carlos Lodeiro, Roberto Solis, William Moritz, Susan Kennedy, Lauren Barron, Emily Onufer, Gianfranco Alpini, Tianhao Zhou and 3 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury.International journal of molecular sciences · 2022
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. CGI-58: Versatile Regulator of Intracellular Lipid Droplet Homeostasis.Advances in experimental medicine and biology · 2020
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Elizabeth P NewberryGastroenterology Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Yan XieGastroenterology Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Carlos LodeiroGastroenterology Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Roberto SolisGastroenterology Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
William MoritzGastroenterology Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Susan KennedyGastroenterology Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Lauren BarronPediatric Surgery Division, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Emily OnuferPediatric Surgery Division, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Gianfranco AlpiniDepartment of Medical Physiology and Internal Medicine, Texas A&M University, Temple, Texas, USA.
Tianhao ZhouDepartment of Medical Physiology and Internal Medicine, Texas A&M University, Temple, Texas, USA.
William S BlanerDepartment of Medicine, Columbia University, New York, New York, USA; and.
Anping ChenDepartment of Pathology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
Nicholas O DavidsonGastroenterology Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Washington University in St. Louis · USColumbia University · USSaint Louis University · USTemple College · USTexas A&M University · US

Funding

Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
Postprandial Vitamin AR01DK068437 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANER, WILLIAM S · 2004 to 2023
$7.0M
HEPATIC SYNTHESIS AND SECRETION OF APOLIPOPROTEIN (A)R01DK056260 · NIDDK · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O. · 1999 to 2017
$5.9M
ENTEROHEPATIC LIPID FLUX AND APOPROTEIN BIOSYNTHESIS.R37HL038180 · NHLBI · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O. · 2000 to 2009
$5.1M
ENTEROHEPATIC LIPID FLUX AND APOPROTEIN BIOSYNTHESISR01HL038180 · NHLBI · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O. · 1986 to 2018
$3.8M
Impaired VLDL secretion, progression and reversal of hepatic fibrogenesisR01DK119437 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2019 to 2026
$3.8M
Vitamin A Homeostasis: Retinyl Ester StoresR01DK101251 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANER, WILLIAM S, HARRISON, EARL HOWARD · 2016 to 2018
$1.4M
Postprandial Vitamin AR56DK068437 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANER, WILLIAM S · 2009 to 2009
$450k
Autocrine/Paracrine Regulation of Intrahepatic Bile Duct GrowthI01BX000574 · VA · RLR VA MEDICAL CENTER · PI ALPINI, GIANFRANCO D · 2009 to 2022
–
BLRD VA I01 BX000574BLRD VA IK6 BX004601NHLBI NIH HHS R01 HL038180NHLBI NIH HHS R37 HL038180NIDDK NIH HHS P30 DK052574NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK056260NIDDK NIH HHS R01 DK068437NIDDK NIH HHS R01 DK101251NIDDK NIH HHS R01 DK119437NIDDK NIH HHS R56 DK068437
6 · The paper itself

Abstract

Liver fatty acid binding protein (L-Fabp) modulates lipid trafficking in enterocytes, hepatocytes, and hepatic stellate cells (HSCs). We examined hepatocyte vs. HSC L-Fabp deletion in hepatic metabolic adaptation and fibrotic injury. Floxed L-Fabp mice were bred to different transgenic Cre mice or injected with adeno-associated virus type 8 (AAV8) Cre and fed diets to promote steatosis and fibrosis or were subjected to either bile duct ligation or CCl

Indexed as

AlbuminsAnimalsBile DuctsCarbon Tetrachloride PoisoningCrosses, GeneticDependovirusDietary FatsFatty Acid-Binding ProteinsFatty AcidsFatty LiverFemaleFibrosisFood DeprivationGene DeletionGenes, SyntheticHepatic Stellate CellsAlbuminsCre recombinaseDietary FatsFabp1 protein, mouseFatty Acid-Binding ProteinsFatty AcidsIntegrasescell-specific Cre-deletionfibrogenesismouse modelssteatohepatitis

Identifiers

PMID30576225
PMCPMC6404585
OpenAlexW2906210096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.