Evidence map›Paper›PMID 30576223›Full record

ArticleAmerican journal of respiratory cell and molecular biology2019

The Club Cell Marker SCGB1A1 Downstream of FOXA2 is Reduced in Asthma.

Lingxiang Zhu, Lingling An, Di Ran, Rosa Lizarraga, Cheryl Bondy, Xu Zhou, Richart W Harper, Shu-Yi Liao, Yin Chen

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Airway epithelial heterogeneity and mucus plugging in asthmatic bronchioles.American journal of respiratory and critical care medicine · 2026
    Article
  6. Article
  7. Unraveling the Causal Linkages ofBioMed research international · 2026
    Article
  8. Review
  9. Article
  10. Pharmacological Gq targeting prevents asthmatic airway remodeling.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  11. Review
  12. Article
  13. Frontiers in immunology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Extracellular vesicle-encapsulated CC16 as novel nanotherapeutics for treatment of acute lung injury.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lingxiang Zhu1 Department of Pharmacology and Toxicology, School of Pharmacy.
Lingling An2 Department of Epidemiology Biostatistics.
Di Ran2 Department of Epidemiology Biostatistics.
Rosa Lizarraga1 Department of Pharmacology and Toxicology, School of Pharmacy.
Cheryl Bondy1 Department of Pharmacology and Toxicology, School of Pharmacy.
Xu Zhou1 Department of Pharmacology and Toxicology, School of Pharmacy.
Richart W Harper5 Department of Internal Medicine, University of California, Davis, California.
Shu-Yi Liao5 Department of Internal Medicine, University of California, Davis, California.
Yin Chen1 Department of Pharmacology and Toxicology, School of Pharmacy.
University of California, Davis · USUniversity of Arizona · US

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
Arsenic exposure, CC16 and its effect on pulmonary functionR01ES027013 · NIEHS · UNIVERSITY OF ARIZONA · PI CHEN, YIN, LANTZ, ROBERT CLARK · 2017 to 2021
$1.7M
Vanadium, Calcineurin, and Pulmonary HealthR21ES028889 · NIEHS · UNIVERSITY OF ARIZONA · PI CHEN, YIN · 2018 to 2019
$434k
Mechanisms of epithelium-directed change of permissiveness for rhinoviral infectionR21AI139439 · NIAID · UNIVERSITY OF ARIZONA · PI CHEN, YIN · 2018 to 2019
$422k
TLR3, TICAM1 and human rhinovirus infectionR21AI113526 · NIAID · UNIVERSITY OF ARIZONA · PI CHEN, YIN · 2014 to 2015
$417k
NIAID NIH HHS R21 AI113526NIAID NIH HHS R21 AI139439NIEHS NIH HHS P30 ES006694NIEHS NIH HHS R01 ES027013NIEHS NIH HHS R21 ES028889
6 · The paper itself

Abstract

Human SCGB1A1 protein has been shown to be significantly reduced in BAL, sputum, and serum from humans with asthma as compared with healthy individuals. However, the mechanism of this reduction and its functional impact have not been entirely elucidated. By mining online datasets, we found that the mRNA of

Indexed as

AnimalsAsthmaBiomarkersCytokinesDisease Models, AnimalDisease ProgressionDown-RegulationEpithelial CellsHepatocyte Nuclear Factor 3-betaHumansMice, Inbred C57BLMice, KnockoutPhenotypeRhinovirusTh2 CellsUteroglobinBiomarkersCytokinesFOXA2 protein, humanFoxa2 protein, mouseHepatocyte Nuclear Factor 3-betaSCGB1A1 protein, humanScgb1a1 protein, mouseUteroglobinasthmaCC10FOXA2rhinovirussecretoglobin

Identifiers

PMID30576223
PMCPMC6543749
OpenAlexW2906599740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.