Evidence map›Paper›PMID 30576088›Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2019

Availability of less invasive prenatal, perinatal and paediatric autopsy will improve uptake rates: a mixed-methods study with bereaved parents.

C Lewis, M Riddington, M Hill, O J Arthurs, J C Hutchinson, L S Chitty, C Bevan, J Fisher, J Ward, N J Sebire

Open access · hybridAbstract read
In one paragraph

Article in BJOG : an international journal of obstetrics and gynaecology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  5. Review
  6. Review
  7. Article
  8. Article
  9. Minimally invasive autopsy - endoscopic approach to post-mortem diagnostics.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2024
    Review
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  13. Review
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  16. Observational
  17. Review
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  20. Feasibility of INTACT (INcisionless TArgeted Core Tissue) biopsy procedure for perinatal autopsy.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

C LewisNorth East Thames Regional Genetics Service, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
M RiddingtonDepartment of Psychological Services, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
M HillNorth East Thames Regional Genetics Service, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
O J ArthursDepartment of Radiology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
J C HutchinsonDepartment of Histopathology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
L S ChittyNorth East Thames Regional Genetics Service, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
C BevanStillbirth and neonatal death charity (Sands), London, UK.
J FisherAntenatal Results and Choices (ARC), London, UK.
J WardThe Lullaby Trust, London, UK.
N J SebireDepartment of Histopathology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
Great Ormond Street Hospital for Children NHS Foundation Trust · GBGreat Ormond Street Hospital · GBLullaby Trust · GBSands · GB

Funding

Department of Health 14/168/02Department of Health CDF-2017-10-037Department of Health HTA/14/168/02Department of Health ICA-CDRF-2017-03-053Great Ormond Street Hospital Children's CharityNational Institute for Health Research (NIHR) Health Technology Assessment 14/168/02NIHR Biomedical Research Centre at Great Ormond Street HospitalNIHR Clinical Scientist Fellowship award NIPR-CS-012-002
6 · The paper itself

Abstract

objectiveTo investigate whether less invasive methods of autopsy would be acceptable to bereaved parents and likely to increase uptake.

designMixed methods study.

settingBereaved parents recruited prospectively across seven hospitals in England and retrospectively through four parent support organisations. SAMPLE: Eight hundred and fifty-nine surveys and 20 interviews with bereaved parents.

methodsCross-sectional survey and qualitative semi-structured telephone interviews.

main outcome measuresLikely uptake, preferences, factors impacting decision-making, views on different autopsy methods.

resultsOverall, 90.5% of participants indicated that they would consent to some form of less invasive autopsy [either minimally invasive autopsy (MIA), non-invasive autopsy (NIA) or both]; 53.8% would consent to standard autopsy, 74.3% to MIA and 77.3% to NIA. Regarding parental preferences, 45.5% preferred MIA, 30.8% preferred NIA and 14.3% preferred standard autopsy. Participants who indicated they would decline standard autopsy but would consent to a less invasive option were significantly more likely to have a lower educational level (odds ratio 0.49; 95% CI 0.35-0.70; P = 0.000062). Qualitative findings suggest that parents value NIA because of the lack of any incision and MIA is considered a good compromise as it enables tissue sampling while easing the parental burden associated with consenting to standard autopsy.

conclusionLess invasive methods of autopsy are acceptable alternatives for bereaved parents, and if offered, are likely to increase uptake and improve parental experience. Further health economic, validation and implementation studies are now required to assess the viability of offering these in routine widespread clinical care. TWEETABLE ABSTRACT: Mixed methods UK study finds less invasive methods of autopsy are acceptable alternatives for bereaved parents, and if offered, are likely to increase uptake and improve parental experience.

Indexed as

Congenital AbnormalitiesStillbirthAborted FetusAutopsyBereavementCounselingCross-Sectional StudiesDecision MakingEnglandFemaleFetal DeathHumansMagnetic Resonance ImagingParentsPerinatal DeathPregnancyAutopsyconsentfetalless invasiveperinatalpost-mortempreferenceprenataluptake

Identifiers

PMID30576088
PMCPMC6519272
OpenAlexW2905774343

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.