ArticleScientific reports2018
An adaptive microbiome α-diversity-based association analysis method.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analysis of gut microbiome reveals patterns of dysbiosis in colorectal cancer patients.Journal of medical microbiology · 2025Pooled it
- Effects of Exercise on Gut Microbiota of Adults: A Systematic Review and Meta-Analysis.Nutrients · 2024Pooled it
- MiSurv: an Integrative Web Cloud Platform for User-Friendly Microbiome Data Analysis with Survival Responses.Microbiology spectrum · 2023Trial
- Substrate-Driven Microbiome Assembly in Water Hyacinth Vermicompost: Combined 16S rRNA and Shotgun Metagenomics for Sustainable Agriculture.Journal of basic microbiology · 2026Article
- Characterization of the Gastric Antrum Microbiome inPathogens (Basel, Switzerland) · 2026Article
- Effects of aerobic exercise on inflammation and gut microbiota in obese mice: a metagenomic and metabolomic analysis.Journal of translational medicine · 2026Article
- Shotgun metagenomic profiling reveals Bacillus-dominated bacterial communities in urban rooftop and surface garden soils of Bangladesh.PloS one · 2026Article
- Article
- Effects of Additives on Fermentation Quality, Nutritional Quality, and Microbial Diversity ofMicroorganisms · 2025Article
- Mix-method toolbox for monitoring greenhouse gas production and microbiome responses to soil amendments.MethodsX · 2024Article
- MiMultiCat: A Unified Cloud Platform for the Analysis of Microbiome Data with Multi-Categorical Responses.Bioengineering (Basel, Switzerland) · 2024Article
- The mediating roles of the oral microbiome in saliva and subgingival sites between e-cigarette smoking and gingival inflammation.BMC microbiology · 2023Article
- Babies, bugs and brains: How the early microbiome associates with infant brain and behavior development.PloS one · 2023Article
- Integrative web cloud computing and analytics using MiPair for design-based comparative analysis with paired microbiome data.Scientific reports · 2022Article
- Induction of mastitis by cow-to-mouse fecal and milk microbiota transplantation causes microbiome dysbiosis and genomic functional perturbation in mice.Animal microbiome · 2022Article
- Comparative study on fecal flora and blood biochemical indexes in normal and diarrhea British Shorthair cats.Archives of microbiology · 2022Article
- Antidiabetic potential of polysaccharides fromCurrent research in food science · 2022Article
- Shared Species Analysis, Augmented by Stochasticity Analysis, Is More Effective Than Diversity Analysis in Detecting Variations in the Gut Microbiomes.Frontiers in microbiology · 2022Article
- Article
- An Adaptive and Robust Test for Microbial Community Analysis.Frontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
1 author.
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Abstract
To relate microbial diversity with various host traits of interest (e.g., phenotypes, clinical interventions, environmental factors) is a critical step for generic assessments about the disparity in human microbiota among different populations. The performance of the current item-by-item α-diversity-based association tests is sensitive to the choice of α-diversity metric and unpredictable due to the unknown nature of the true association. The approach of cherry-picking a test for the smallest p-value or the largest effect size among multiple item-by-item analyses is not even statistically valid due to the inherent multiplicity issue. Investigators have recently introduced microbial community-level association tests while blustering statistical power increase of their proposed methods. However, they are purely a test for significance which does not provide any estimation facilities on the effect direction and size of a microbial community; hence, they are not in practical use. Here, I introduce a novel microbial diversity association test, namely, adaptive microbiome α-diversity-based association analysis (aMiAD). aMiAD simultaneously tests the significance and estimates the effect score of the microbial diversity on a host trait, while robustly maintaining high statistical power and accurate estimation with no issues in validity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.