Evidence map›Paper›PMID 30575790›Full record

ArticleScientific reports2018

The microRNA-183/96/182 Cluster is Essential for Stereociliary Bundle Formation and Function of Cochlear Sensory Hair Cells.

Ruishuang Geng, David N Furness, Chithra K Muraleedharan, Jinsheng Zhang, Alain Dabdoub, Vincent Lin, Shunbin Xu

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Analysis of miRNAs from Inner Ear Organoid-Derived Extracellular Vesicles.Journal of the Association for Research in Otolaryngology : JARO · 2025
    Article
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  9. Review
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  14. Review
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  17. NcRNA: key and potential in hearing loss.Frontiers in neuroscience · 2023
    Review
  18. Article
  19. Integrating pharmacogenomics into clinical trials of hearing disorders.The Journal of the Acoustical Society of America · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Ruishuang GengDepartment of Ophthalmology, Visual and Anatomical Sciences, School of Medicine, Wayne State University, Detroit, Michigan, USA. ruishuang@gmail.com.
David N FurnessSchool of Life Sciences, Keele University, Keele, Staffs, ST5 5BG, United Kingdom.
Chithra K MuraleedharanDepartment of Ophthalmology, Visual and Anatomical Sciences, School of Medicine, Wayne State University, Detroit, Michigan, USA.
Jinsheng ZhangDepartment of Otolaryngology, School of Medicine, Wayne State University, Detroit, Michigan, USA.
Alain DabdoubBiological Science, Sunnybrook Research Institute, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-4259-2425
Vincent LinBiological Science, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Shunbin XuDepartment of Ophthalmology, Visual and Anatomical Sciences, School of Medicine, Wayne State University, Detroit, Michigan, USA. sxu@med.wayne.edu.
Wayne State University · USSunnybrook Hospital · CAKeele University · GB

Funding

VISION RESEARCH--COREP30EY004068 · NEI · WAYNE STATE UNIVERSITY · PI LINDA D HAZLETT · 1985 to 2026
$13.2M
The miR-183/96/182 Cluster in Pseudomonas aeruginosa-induced KeratitisR01EY026059 · NEI · WAYNE STATE UNIVERSITY · PI SHUNBIN XU · 2017 to 2026
$3.7M
NEI NIH HHS P30 EY004068NEI NIH HHS R01 EY026059Research to Prevent Blindness (RPB) unrestricted grantU.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) P30EY004068U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) R01EY026059
6 · The paper itself

Abstract

The microRNA (miR)-183/96/182 cluster plays important roles in the development and functions of sensory organs, including the inner ear. Point-mutations in the seed sequence of miR-96 result in non-syndromic hearing loss in both mice and humans. However, the lack of a functionally null mutant has hampered the evaluation of the cluster's physiological functions. Here we have characterized a loss-of-function mutant mouse model (miR-183C

Indexed as

AnimalsAnimals, NewbornCells, CulturedHair Cells, AuditoryHair Cells, Auditory, InnerMiceMice, Inbred C57BLMice, KnockoutMicroRNAsMorphogenesisMultigene FamilyStereociliaMicroRNAsMirn182 microRNA, mouseMirn183 microRNA, mouseMirn96 microRNA, mouse

Identifiers

PMID30575790
PMCPMC6303392
OpenAlexW2904339111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.