Evidence map›Paper›PMID 30575745›Full record

ArticleNature communications2018

Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice.

Dalong Ni, Dawei Jiang, Christopher J Kutyreff, Jianhao Lai, Yongjun Yan, Todd E Barnhart, Bo Yu, Hyung-Jun Im, Lei Kang, Steve Y Cho and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 298 citations in OpenAlex.

  1. Review
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  19. NADNature biomedical engineering · 2025
    Article
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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Dalong NiDepartments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, 53705, USA.
Dawei JiangDepartments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, 53705, USA.ORCID http://orcid.org/0000-0002-4072-0075
Christopher J KutyreffDepartments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, 53705, USA.
Jianhao LaiDepartments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, 53705, USA.
Yongjun YanDepartments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, 53705, USA.
Todd E BarnhartDepartments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, 53705, USA.ORCID http://orcid.org/0000-0002-9981-2150
Bo YuDepartments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, 53705, USA.
Hyung-Jun ImDepartments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, 53705, USA.
Lei KangDepartments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, 53705, USA.
Steve Y ChoDepartments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, 53705, USA.
Zhaofei LiuMedical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, 100191, Beijing, China. liuzf@bjmu.edu.cn.ORCID http://orcid.org/0000-0001-8718-8154
Peng HuangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, 518060, Shenzhen, China.ORCID http://orcid.org/0000-0003-3651-7813
Jonathan W EngleDepartments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, 53705, USA.
Weibo CaiDepartments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, 53705, USA. wcai@uwhealth.org.ORCID http://orcid.org/0000-0003-4641-0833
University of Wisconsin–Madison · USPeking University · CNShenzhen University · CN

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
NCI NIH HHS P30 CA014520
6 · The paper itself

Abstract

Acute kidney injury (AKI) is a common reactive oxygen species (ROS)-related renal disease that causes numerous deaths annually, yet only supportive treatment is currently available in the clinics. Development of antioxidants with high accumulation rates in kidneys is highly desired to help prevent AKI. Here we report molybdenum-based polyoxometalate (POM) nanoclusters with preferential renal uptake as novel nano-antioxidants for kidney protection. These POM nanoclusters, with a readily variable valence state of molybdenum ions, possess the capability to scavenge detrimental ROS. Our results demonstrate that POM nanoclusters can efficiently alleviate clinical symptoms in mice subjected to AKI, as verified by dynamic PET imaging with

Indexed as

Acute Kidney InjuryAnimalsAntioxidantsBiomarkersDrug Evaluation, PreclinicalFemaleKidneyMice, Inbred ICRMolybdenumNanostructuresPositron-Emission TomographyReactive Oxygen SpeciesAntioxidantsBiomarkersMolybdenumReactive Oxygen Species

Identifiers

PMID30575745
PMCPMC6303396
OpenAlexW2905491630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.