ArticleNature communications2018
Ezh2 programs T
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Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
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Who cites it
48 citing papers in PubMed, 79 citations in OpenAlex.
- Mapping self-associating chromatin hubs identifies Id proteins as key determinants of exhausted CD8Nature immunology · 2026Article
- Targeting Mettl8-Tcf1 axis promotes CD8+ TPEX differentiation and antitumor immunity.The Journal of experimental medicine · 2026Article
- Epigenetic modifications in cancer drug resistance: molecular mechanisms and therapeutic interventions.Molecular biomedicine · 2026Review
- Identification of a neoplastic Tfh-like cellular subset in a mouse model of angioimmunoblastic T cell lymphoma.Frontiers in oncology · 2026Article
- Targeting EZH2 in autoimmune diseases: unraveling epigenetic regulation and therapeutic potential.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Enhancer zeste homolog 2 (EZH2) targeting by small interfering RNA (siRNA); recent advances and prospect.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- EZH2 loss promotes gastric squamous cell carcinoma.Nature communications · 2025Article
- KMT2D coordinates antiviral CD4Cell reports · 2025Article
- Mechanisms and Therapeutic Implications of EZH2 in Nasal Diseases.Clinical reviews in allergy & immunology · 2025Review
- Intracellular checkpoints for NK cell cancer immunotherapy.Frontiers of medicine · 2024Review
- Transcriptional regulation of Tfh dynamics and the formation of immunological synapses.Experimental & molecular medicine · 2024Review
- Review
- Key Functions of the Transcription Factor BCL6 During T-Cell Differentiation.Advances in experimental medicine and biology · 2024Review
- The multifaceted roles of TCF1 in innate and adaptive lymphocytes.Advances in immunology · 2024Review
- Phosphorylation of EZH2 differs HER2-positive breast cancer invasiveness in a site-specific manner.BMC cancer · 2023Article
- Analysis on EZH2: mechanism identification of related CeRNA and its immunoassay in hepatocellular carcinoma.BMC medical genomics · 2023Article
- The Chromatin Regulator Mll1 Supports T Follicular Helper Cell Differentiation by Controlling Expression of Bcl6, LEF-1, and TCF-1.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- CTCF mediates CD8+ effector differentiation through dynamic redistribution and genomic reorganization.The Journal of experimental medicine · 2023Article
- The pleiotropic roles of EZH2 in T-cell immunity and immunotherapy.International journal of hematology · 2022Review
- The Transcription Factor YY-1 Is an Essential Regulator of T Follicular Helper Cell Differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Fengyin LiInstitutes for Translational Medicine, Soochow University, Suzhou, Jiangsu, P. R. China, 215123.
Zhouhao ZengDepartment of Physics, The George Washington University, Washington DC, 20052, USA.
Shaojun XingDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA, 52242.
Jodi A GullicksrudDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA, 52242.
Qiang ShanDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA, 52242.
Jinyong ChoiLa Jolla Institute, La Jolla, CA, USA, 92037.
Vladimir P BadovinacDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA, 52242.
Shane CrottyLa Jolla Institute, La Jolla, CA, USA, 92037.ORCID http://orcid.org/0000-0002-6484-6262
Weiqun PengDepartment of Physics, The George Washington University, Washington DC, 20052, USA.
Hai-Hui XueDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA, 52242. hai-hui-xue@uiowa.edu.ORCID http://orcid.org/0000-0002-9163-7669
University of Iowa · USGeorge Washington University · USLa Jolla Institute for Immunology · US
Funding
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0MTcf/Lef-b-catenin in T cell identity and cancerR01AI112579 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2015 to 2026
$5.4MTfh and SAP and T cell help to B cellsR01AI072543 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROTTY, SHANE P · 2008 to 2018
$4.6MTcf/Lef and B-catenin pathway in follicular helper T cellsR01AI121080 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2016 to 2026
$4.6MMemory CD8 T cell localization and protection from influenzaR01AI114543 · NIAID · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P, HARTY, JOHN T · 2015 to 2024
$4.4MEzh2 regulates follicular helper T cell differentiationR01AI139874 · NIAID · UNIVERSITY OF IOWA · PI PENG, WEIQUN, XUE, HAI-HUI · 2018 to 2022
$2.4MImpairment and recovery of CD8 T cell responses after sepsisR01GM113961 · NIGMS · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P · 2015 to 2018
$1.2MFlow Cytometry Cell SorterS10OD016199 · OD · UNIVERSITY OF IOWA · PI BALLAS, ZUHAIR K. · 2015 to 2015
$443kMolecular mechanisms controlling differentiation of memory CD8 T cellsR21AI119160 · NIAID · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P, XUE, HAI-HUI · 2015 to 2016
$414kTargeting Tcf/Lef-transcriptional program in leukemic stem cellsI01BX002903 · VA · VA NEW JERSEY HEALTH CARE SYSTEM · PI XUE, HAI-HUI · 2016 to 2019
–BLRD VA I01 BX002903NCI NIH HHS P30 CA086862NIAID NIH HHS R01 AI072543NIAID NIH HHS R01 AI112579NIAID NIH HHS R01 AI114543NIAID NIH HHS R01 AI121080NIAID NIH HHS R01 AI139874NIAID NIH HHS R21 AI119160NIGMS NIH HHS R01 GM113961NIH HHS S10 OD016199
Abstract
Ezh2 is an histone methyltransferase (HMT) that catalyzes H3K27me3 and functions in T
Indexed as
AnimalsCell DifferentiationCell SurvivalCyclin-Dependent Kinase Inhibitor p16Enhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticGene Expression RegulationHepatocyte Nuclear Factor 1-alphaMice, Inbred C57BLMice, TransgenicPhosphorylationProto-Oncogene Proteins c-bcl-6T-Lymphocytes, Helper-InducerVirus DiseasesBcl6 protein, mouseCdkn2a protein, mouseCyclin-Dependent Kinase Inhibitor p16Enhancer of Zeste Homolog 2 ProteinEzh2 protein, mouseHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseProto-Oncogene Proteins c-bcl-6
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.