Evidence map›Paper›PMID 30575736›Full record

ArticleNature communications2018

Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma.

Gary L Gallia, Ming Zhang, Yi Ning, Michael C Haffner, Denise Batista, Zev A Binder, Justin A Bishop, Christine L Hann, Ralph H Hruban, Masaru Ishii and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 40 citations in OpenAlex.

  1. Exploring Dystrophin Expression and Mutations in theInternational journal of molecular sciences · 2026
    Article
  2. Molecular Profiling of Olfactory Neuroblastoma Using the AACR Project GENIE Database.Journal of neurological surgery. Part B, Skull base · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Update on olfactory neuroblastoma.Virchows Archiv : an international journal of pathology · 2024
    Review
  10. Therapeutic approaches for Duchenne muscular dystrophy.Nature reviews. Drug discovery · 2023
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. A Review on Esthesioneuroblastoma.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
    Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 5 institutions in 1 country.

Gary L GalliaDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. ggallia1@jhmi.edu.
Ming ZhangLudwig Center for Cancer Genetics and Therapeutics, Department of Oncology and Pathology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Yi NingDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Michael C HaffnerDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Denise BatistaDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Zev A BinderDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Justin A BishopDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Christine L HannDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Ralph H HrubanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Masaru IshiiDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Alison P KleinDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Douglas D RehDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Lisa M RooperDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Vafi SalmasiDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Rafael J TamargoDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Qing WangLudwig Center for Cancer Genetics and Therapeutics, Department of Oncology and Pathology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Tara WilliamsonDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Tianna ZhaoDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Ying ZouDepartment of Pathology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Alan K MeekerDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Nishant AgrawalDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Bert VogelsteinLudwig Center for Cancer Genetics and Therapeutics, Department of Oncology and Pathology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Kenneth W KinzlerLudwig Center for Cancer Genetics and Therapeutics, Department of Oncology and Pathology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Nickolas PapadopoulosLudwig Center for Cancer Genetics and Therapeutics, Department of Oncology and Pathology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. npapado1@jhmi.edu.
Chetan BettegowdaDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. cbetteg1@jhmi.edu.
Johns Hopkins University · USJohns Hopkins Medicine · USCancer Genetics (United States) · USUniversity of Maryland, Baltimore · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Olfactory neuroblastoma (ONB) is a rare malignant neoplasm arising in the upper portion of the sinonasal cavity. To better understand the genetic bases for ONB, here we perform whole exome and whole genome sequencing as well as single nucleotide polymorphism array analyses in a series of ONB patient samples. Deletions involving the dystrophin (DMD) locus are found in 12 of 14 (86%) tumors. Interestingly, one of the remaining tumors has a deletion in LAMA2, bringing the number of ONBs with deletions of genes involved in the development of muscular dystrophies to 13 or 93%. This high prevalence implicates an unexpected functional role for genes causing hereditary muscular dystrophies in ONB.

Identifiers

PMID30575736
PMCPMC6303314
OpenAlexW2904828934

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.