ArticleNature communications2018
Molecular and functional heterogeneity of IL-10-producing CD4
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Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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81citing papers in PubMed
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Who cites it
81 citing papers in PubMed.
- Depletion of LAG-3Clinical pharmacology and therapeutics · 2021Trial
- Antigen-specific type 1 regulatory T cell responses shape immunity and disease tolerance in human malaria.The Journal of clinical investigation · 2026Article
- IL-10 attenuates metabolic dysfunction-associated steatotic liver disease via modulation of hepatic responses to lipotoxicity.JCI insight · 2026Article
- T-bet-expressing Tr1 cells driven by dietary signals dominate the small intestinal immune landscape.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Allospecific splenic Tr1 cells drive effector T cell exhaustion through up-regulated Areg-EGFR signaling to promote transplant tolerance.Science advances · 2026Article
- Engineering allogeneic type 1 regulatory T cells: a scalable, off-the-shelf platform for restoring immune tolerance.Frontiers in immunology · 2026Article
- Characterization of the SARS-CoV-2-Specific T Cell Responses in Rheumatoid Arthritis Subjects Vaccinated for COVID-19 Protection.European journal of immunology · 2025Article
- Rheumatoid arthritis synovial fibroblasts modulate T cell activation.JCI insight · 2025Article
- Interleukin 10 controls the balance between tolerance, pathogen elimination, and immunopathology in birds.eLife · 2025Article
- IL-21-dependent Ly6CCell death discovery · 2025Article
- Microbiota-dependent modulation of intestinal anti-inflammatory CD4Seminars in immunopathology · 2025Review
- Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study.Open medicine (Warsaw, Poland) · 2025Article
- Bronchial anastomotic complications as a microvascular disruption in a mouse model of airway transplantation.Frontiers in immunology · 2025Review
- Interleukin 35-producing B cells prolong the survival of GVHD mice by secreting exosomes with membrane-bound IL-35 and upregulating PD-1/LAG-3 checkpoint proteins.Theranostics · 2025Article
- Effects of maternal-offspring supplementation of probiotics and synbiotics on the immunity of offspring Bama mini-pigs.Frontiers in immunology · 2025Article
- Article
- A novel Slide-seq based image processing software to identify gene expression at the single cell level.Journal of pathology informatics · 2024Article
- Enhanced Effect ofNutrients · 2024Article
- Strategies for targeting cytokines in inflammatory bowel disease.Nature reviews. Immunology · 2024Review
- The role of immune-inflammatory markers in children with complicated and uncomplicated malaria in Enugu, Nigeria.BMC immunology · 2024Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
28 authors.
Leonie BrockmannI. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Shiwa SoukouI. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Babett SteglichI. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Paulo CzarnewskiImmunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-8150-4021
Lilan ZhaoDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Sandra WendeI. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Tanja BedkeI. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Can ErgenI. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Carolin MantheyI. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Theodora AgaliotiDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Maria GeffkenInstitute of Transfusion Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Oliver SeizI. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Sara M ParigiImmunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden.
Chiara SoriniImmunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-6803-8377
Jens GeginatINGM-National Institute of Molecular Genetics "Romeo ed Enrica Invernizzi", 20122, Milan, Italy.
Keishi FujioDepartment of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 113-8655, Tokyo, Japan.
Thomas JacobsDepartment of Immunology, Bernhard-Nocht-Institute of Tropical Medicine, 20359, Hamburg, Germany.
Thomas RoeschDepartment for Interdisciplinary Endoscopy, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Jacob R IzbickiDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Ansgar W LohseI. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Richard A FlavellDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT, 06520, USA.ORCID http://orcid.org/0000-0003-4461-0778
Christian KrebsIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Jan-Ake GustafssonDepartment of Biosciences and Nutrition, Karolinska Institutet, 17177, Stockholm, Sweden.
Per AntonsonDepartment of Biosciences and Nutrition, Karolinska Institutet, 17177, Stockholm, Sweden.
Maria Grazia RoncaroloDivision of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, ISCBRM, Stanford School of Medicine, 94304, Stanford, CA, USA.
Eduardo J VillablancaImmunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-9522-9729
Nicola GaglianiI. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany. n.gagliani@uke.de.
Samuel HuberI. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany. shuber@uke.de.
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MAbstract
IL-10 is a prototypical anti-inflammatory cytokine, which is fundamental to the maintenance of immune homeostasis, especially in the intestine. There is an assumption that cells producing IL-10 have an immunoregulatory function. However, here we report that IL-10-producing CD4
Indexed as
AnimalsCD4-Positive T-LymphocytesHumansInflammatory Bowel DiseasesInterleukin-10Mice, Inbred C57BLSingle-Cell AnalysisTranscriptomeIL10 protein, humanIL10 protein, mouseInterleukin-10
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.