ArticleActa crystallographica. Section A, Foundations and advances2019
Reducing dynamical electron scattering reveals hydrogen atoms.
Article in Acta crystallographica. Section A, Foundations and advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Hydride and Seek: Comparing Crystallographic Hydride Placement Techniques with an Open-Shell Cobalt Complex.ACS central science · 2026Article
- Application of electron diffraction to rapid structural elucidation of crude reaction products.Communications chemistry · 2026Article
- Advances of 3D microcrystals electron diffraction for transmembrane protein structure determination.Biophysical journal · 2026Review
- Article
- Room-temperature structure determination of vacuum-sensitive organic compounds by formvar encapsulation and serial electron diffraction.Journal of applied crystallography · 2025Article
- Structure of L-arginine and detection of trace DL-arginine by 3D ED.Acta crystallographica. Section C, Structural chemistry · 2025Article
- Doses for X-ray and electron diffraction: New features in RADDOSE-3D including intensity decay models.Protein science : a publication of the Protein Society · 2024Article
- Reaching the potential of electron diffraction.Cell reports. Physical science · 2024Article
- High Temperature Electron Diffraction on Organic Crystals:Journal of the American Chemical Society · 2024Article
- Measurement of charges and chemical bonding in a cryo-EM structure.Communications chemistry · 2023Article
- Structural resolution of a small organic molecule by serial X-ray free-electron laser and electron crystallography.Nature chemistry · 2023Article
- Direct structure determination of vemurafenib polymorphism from compact spherulites using 3D electron diffraction.Communications chemistry · 2023Article
- Electron Diffraction of 3D Molecular Crystals.Chemical reviews · 2022Review
- Visualizing the Entire Range of Noncovalent Interactions in Nanocrystalline Hybrid Materials Using 3D Electron Diffraction.Journal of the American Chemical Society · 2022Article
- Article
- Review
- Hydrogens and hydrogen-bond networks in macromolecular MicroED data.Journal of structural biology: X · 2022Article
- Metalloprotein catalysis: structural and mechanistic insights into oxidoreductases from neutron protein crystallography.Acta crystallographica. Section D, Structural biology · 2021Review
- Structure Solution of Nano-Crystalline Small Molecules Using MicroED and Solid-State NMR Dipolar-Based Experiments.Molecules (Basel, Switzerland) · 2021Article
- Macromolecular crystallography using microcrystal electron diffraction.Acta crystallographica. Section D, Structural biology · 2021Review
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Authors and funding
4 authors.
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Abstract
Compared with X-rays, electron diffraction faces a crucial challenge: dynamical electron scattering compromises structure solution and its effects can only be modelled in specific cases. Dynamical scattering can be reduced experimentally by decreasing crystal size but not without a penalty, as it also reduces the overall diffracted intensity. In this article it is shown that nanometre-sized crystals from organic pharmaceuticals allow positional refinement of the hydrogen atoms, even whilst ignoring the effects of dynamical scattering during refinement. To boost the very weak diffraction data, a highly sensitive hybrid pixel detector was employed. A general likelihood-based computational approach was also introduced for further reducing the adverse effects of dynamic scattering, which significantly improved model accuracy, even for protein crystal data at substantially lower resolution.
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