Evidence map›Paper›PMID 30575518›Full record

ArticleeLife2018

The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in

Gregory M Davis, Shikui Tu, Joshua Wt Anderson, Rhys N Colson, Menachem J Gunzburg, Michelle A Francisco, Debashish Ray, Sean P Shrubsole, Julia A Sobotka, Uri Seroussi and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 3 countries.

Gregory M Davis *Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
Shikui Tu *Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, United States.
Joshua Wt Anderson *Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
Rhys N ColsonDevelopment and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
Menachem J GunzburgDevelopment and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
Michelle A FranciscoDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.
Debashish RayDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.
Sean P ShrubsoleDevelopment and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
Julia A SobotkaDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.
Uri SeroussiDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.
Robert X LaoDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.
Tuhin MaityDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.
Monica Z WuDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.
Katherine McJunkinLaboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, United States.
Quaid D MorrisDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.
Timothy R HughesDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.
Jacqueline A WilceDevelopment and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
Julie M ClaycombDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.
Zhiping WengProgram in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, United States.
Peter R BoagDevelopment and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.ORCID https://orcid.org/0000-0002-0889-0859
University of Toronto · CAMonash University · AUUniversity of Massachusetts Chan Medical School · USFederation University · AUNational Institutes of Health · US

Funding

Biological functions and post-transcriptional regulation of microRNAsZIADK075147 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI MCJUNKIN, KATHERINE · 2018 to 2025
$14.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Understanding the architecture, regulation, and function of piRNA-producing genesP01HD078253 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WENG, ZHIPING · 2015 to 2019
$6.5M
CIHR CAP- 783 262134CIHR MOP-125894CIHR MOP-274660NICHD NIH HHS P01 HD078253NIDDK NIH HHS DK075147NIH HHS HD078253NIH HHS P40 OD010440
6 · The paper itself

Abstract

Proper regulation of germline gene expression is essential for fertility and maintaining species integrity. In the

Indexed as

RNA InterferenceAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCarrier ProteinsChromatinGene Regulatory NetworksGerm CellsCaenorhabditis elegans ProteinsCarrier ProteinsChromatinNHL-2 protein, C elegans22G RNAsCaenorhabditis elegansC. eleganschromosomesgene expressiongeneticsgenomicsRNAismall RNAsTRIM-NHL

Identifiers

PMID30575518
PMCPMC6351104
OpenAlexW2906664098

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.