ArticleAging cell2019
MPK-1/ERK is required for the full activity of resveratrol in extended lifespan and reproduction.
Article in Aging cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
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- Dietary salt promotes cognitive impairment through repression of SIRT3/PINK1-mediated mitophagy and fission.Molecular and cellular biochemistry · 2025Article
- Rosavin extends lifespan via the insulin/IGF-1 signaling pathway in Caenorhabditis elegans.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
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- Carpesii fructus extract exhibits neuroprotective effects in cellular and Caenorhabditis elegans models of Parkinson's disease.CNS neuroscience & therapeutics · 2024Article
- Genetic and Chemical Controls of Sperm Fate and Spermatocyte Dedifferentiation via PUF-8 and MPK-1 inCells · 2023Article
- Article
- Mitogen-Activated Protein Kinase and Substrate Identification in Plant Growth and Development.International journal of molecular sciences · 2022Review
- Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function.Biogerontology · 2022Article
- Genes and Longevity of Lifespan.International journal of molecular sciences · 2022Review
- Roles of tRNA metabolism in aging and lifespan.Cell death & disease · 2021Review
- Review
- Synthesis of Novel Pinocembrin Amino Acid Derivatives and Their Antiaging Effect onDrug design, development and therapy · 2021Article
- The Review of Anti-aging Mechanism of Polyphenols onFrontiers in bioengineering and biotechnology · 2021Review
- A Novel Micronutrient Blend Mimics Calorie Restriction Transcriptomics in Multiple Tissues of Mice and Increases Lifespan and Mobility inNutrients · 2020Article
- The dietary triterpenoid 18α-Glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway.Redox biology · 2020Article
- Polyphenols and Metabolites Enhance Survival in Rodents and Nematodes-Impact of Mitochondria.Nutrients · 2019Article
- MPK-1/ERK is required for the full activity of resveratrol in extended lifespan and reproduction.Aging cell · 2019Article
- Synthetic Imine Resveratrol Analog 2-Methoxyl-3,6-Dihydroxyl-IRA Ameliorates Colitis by Activating Protective Nrf2 Pathway and Inhibiting NLRP3 Expression.Oxidative medicine and cellular longevity · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Resveratrol (RSV) extends the lifespan of various organisms through activation of sirtuin. However, whether RSV-mediated longevity is entirely dependent upon sirtuin is still controversial. Thus, understanding additional mechanisms concerning the genetic requirements for the biological activity of RSV needs to be clarified to utilize the beneficial effects of RSV. In this study using Caenorhabditis elegans as a model system, we found that MPK-1 (an ERK homolog) signaling is necessarily required for RSV-mediated longevity of sir-2.1/sirtuin mutants as well as for wild-type worms. We demonstrated that MPK-1 contributes to RSV-mediated longevity through nuclear accumulation of SKN-1 in a SIR-2.1/DAF-16 pathway-independent manner. The positive effect of RSV in regulating lifespan was completely abolished by RNA interference against mpk-1 in the sir-2.1 and daf-16 mutants, strongly indicating that the MPK-1/SKN-1 pathway is involved in RSV-mediated longevity, independently of SIR-2.1/DAF-16. We additionally found that RSV protected worms from oxidative stress via MPK-1. In addition to organismal aging, RSV prevented the age-associated loss of mitotic germ cells, brood size, and reproductive span through MPK-1 in C. elegans germline. Therefore, our findings not only provide new mechanistic insight into the controversial effects of RSV on organismal longevity, but additionally have important implications in utilizing RSV to improve the outcome of aging-related diseases.
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