Evidence map›Paper›PMID 30575184›Full record

ArticleJournal of magnetic resonance imaging : JMRI2019

Intra- and interreader reproducibility of PI-RADSv2: A multireader study.

Clayton P Smith, Stephanie A Harmon, Tristan Barrett, Leonardo K Bittencourt, Yan Mee Law, Haytham Shebel, Julie Y An, Marcin Czarniecki, Sherif Mehralivand, Mehmet Coskun and 5 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 1 synthesis or guideline pooled it.

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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Clayton P SmithMolecular Imaging Program, National Cancer Institute, NIH, Bethesda, Maryland, USA.ORCID 0000-0002-8509-6237
Stephanie A HarmonClinical Monitoring Research Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD, USA.
Tristan BarrettDepartment of Radiology, Addenbrooke's Hospital and the University of Cambridge, Cambridge, UK.
Leonardo K BittencourtDepartment of Radiology, Fluminese Federal University, Rio de Janeiro, Brazil.ORCID 0000-0001-9175-9626
Yan Mee LawDepartment of Diagnostic Radiology, Singapore General Hospital, Singapore.
Haytham ShebelDepartment of Radiology, Urology Center, Mansoura University, Mansoura City, Egypt.
Julie Y AnNortheast Ohio Medical University, Rootstown, Ohio, USA.
Marcin CzarnieckiMolecular Imaging Program, National Cancer Institute, NIH, Bethesda, Maryland, USA.ORCID 0000-0002-6786-9910
Sherif MehralivandMolecular Imaging Program, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Mehmet CoskunDepartment of Radiology, Dr. Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital, University of Health Sciences, Ýzmir, Turkey.
Bradford J WoodDepartment of Interventional Oncology, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Peter A PintoUrologic Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Joanna H ShihBiometric Research Program, National Cancer Institute, NIH, Rockville, Maryland, USA.
Peter L ChoykeMolecular Imaging Program, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Baris TurkbeyMolecular Imaging Program, National Cancer Institute, NIH, Bethesda, Maryland, USA.ORCID 0000-0003-0853-6494

Funding

Prostate Cancer ImagingZIABC010655 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHOYKE, PETER L · 2009 to 2025
$49.2M
Interventional OncologyZIACL040015 · CLC · CLINICAL CENTER · PI WOOD, BRADFORD · 2009 to 2025
$0k
Cancer Research UK 16465CCR NIH HHS HHSN261200800001CIntramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA CL040015NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

backgroundThe Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) has been in use since 2015; while interreader reproducibility has been studied, there has been a paucity of studies investigating the intrareader reproducibility of PI-RADSv2. PURPOSE: To evaluate both intra- and interreader reproducibility of PI-RADSv2 in the assessment of intraprostatic lesions using multiparametric magnetic resonance imaging (mpMRI). STUDY TYPE: Retrospective. POPULATION/SUBJECTS: In all, 102 consecutive biopsy-naïve patients who underwent prostate MRI and subsequent MR/transrectal ultrasonography (MR/TRUS)-guided biopsy. FIELD STRENGTH/SEQUENCES: Prostate mpMRI at 3T using endorectal with phased array surface coils (TW MRI, DW MRI with ADC maps and b2000 DW MRI, DCE MRI). ASSESSMENT: Previously detected and biopsied lesions were scored by four readers from four different institutions using PI-RADSv2. Readers scored lesions during two readout rounds with a 4-week washout period. STATISTICAL TESTS: Kappa (κ) statistics and specific agreement (P

resultsOverall intrareader reproducibility was moderate to substantial (κ = 0.43-0.67, P DATA

conclusionPI-RADSv2 provides moderate intrareader reproducibility, poor interreader reproducibility, and moderate interreader lesion measurement reproducibility. These findings suggest a need for more standardized reader training in prostate MRI. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2.

Indexed as

Diffusion Magnetic Resonance ImagingMultiparametric Magnetic Resonance ImagingUltrasonographyAdultAgedAged, 80 and overAlgorithmsBiopsyContrast MediaHumansImage-Guided BiopsyMagnetic Resonance ImagingMaleMiddle AgedObserver VariationProstateContrast MediaProstate-Specific AntigenMRIPI-RADSprostate cancerreader reproducibility

Identifiers

PMID30575184
PMCPMC6504619

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.