ArticleIndian journal of ophthalmology2019
Pythium keratitis in South India: Incidence, clinical profile, management, and treatment recommendation.
Article in Indian journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 66 citations in OpenAlex.
- Renaissance of an Emerging Pathogen-Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Modified tectonic corneoscleral graft technique for treating devastating corneoscleral infections.BMC ophthalmology · 2024Article
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- Breaking-Down Barriers: Proposal of Using Cellulose Biosynthesis Inhibitors and Cellulase Enzyme as a Novel Treatment Modality for Vision Threatening Pythium Insidiosum Keratitis.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Case Report: Poor Outcome Despite Aggressive Management in Pythium insidiosum Endophthalmitis.The American journal of tropical medicine and hygiene · 2023Article
- Outcomes of Pythium keratitis: a meta-analysis of individual patient data.Current ophthalmology reports · 2022Article
- Pythium insidiosum Keratitis: Past, Present, and Future.Ophthalmology and therapy · 2022Review
- Clinical differentiation ofIndian journal of ophthalmology · 2022Article
- Role of Immunotherapy in Pythium insidiosum Keratitis.The American journal of tropical medicine and hygiene · 2022Article
- Review
- Global Distribution and Clinical Features of Pythiosis in Humans and Animals.Journal of fungi (Basel, Switzerland) · 2022Article
- Sensitivity and specificity of potassium hydroxide and calcofluor white stain to differentiate between fungal andIndian journal of ophthalmology · 2022Article
- History and Perspective of Immunotherapy for Pythiosis.Vaccines · 2021Review
- Article
- Commentary: A retrospective multifactorial analysis of Pythium keratitis and review of the literature.Indian journal of ophthalmology · 2021Article
- Retrospective multifactorial analysis ofIndian journal of ophthalmology · 2021Review
- Identification and Biotyping ofJournal of fungi (Basel, Switzerland) · 2021Article
- Clinical Characteristics, Histopathology, and Treatment Outcomes ofClinical ophthalmology (Auckland, N.Z.) · 2021Article
- Human Pythiosis: Emergence of Fungal-Like Organism.Mycopathologia · 2020Review
- Article
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo study the demographic profile, clinical features, treatment outcome, and ocular morbidity of microbiologically proven Pythium keratitis in South India.
methodsA retrospective analysis of clinical records of microbiologically proven Pythium keratitis at a tertiary eye care referral center in South India from January 2016 to November 2017 was performed. Demographic details, predisposing risk factors, microbiological investigations, clinical course, and visual outcome were analyzed.
resultsSeventy-one patients with microbiologically proven Pythium keratitis were identified. The mean age was 44(±18.2) years with an increase in male preponderance and 50% were farmers. Duration of delay at time of presentation to the hospital was a mean of 14(±7.2) days. The visual acuity at baseline ranged from 6/6 to no light perception (median 2.1 logMAR). A combination of 5% natamycin and 1% voriconazole was given to 42% patients, and natamycin alone was given to 39.4% patients. 1% itraconazole eye drops alone was initiated in 7 (10%) patients and 3 among this group responded. Therapeutic keratoplasty (TPK) was performed in 48 (67.6%) patients. None of the primary grafts remained clear after a period of 1 month. Twenty-six eyes (54.2%) had graft reinfection and all these eyes either developed anterior staphyloma (4) or were eviscerated (3) and 13 eyes became phthisical. The remaining 22 patients who had TPK resulted in failed graft. Among these, re-grafts were performed in 6 patients, of which 5 were doing well at the last follow-up.
conclusionWe report a large series of patients with Pythium keratitis. Promoting early and differential diagnosis, awareness of clinicians and specific treatment options are needed for this devastating corneal disease.
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