Observational studyIndian journal of ophthalmology2019
Dopamine levels in human tear fluid.
Observational study in Indian journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Dopamine receptors in ocular surface biology: Current evidence and future directions.Indian journal of ophthalmology · 2026Review
- Toward Non-Invasive Neurological Biomarker Monitoring: Dopamine Sensing in Tears with Laser-Induced Graphene Electrochemical Sensors.ACS omega · 2026Article
- Towards real-time additive-free dopamine detection at 10Nature communications · 2026Article
- Development of Quantum dot-based enzyme biosensor for the detection of dopamine in urine.Scientific reports · 2026Article
- Bilisense: An affordable sensor for on-site diagnosis of jaundice and prevention of kernicterus.Biosensors & bioelectronics · 2025Article
- Evaluation of electrodeposition synthesis of gold nanodendrite on screen-printed carbon electrode for nonenzymatic ascorbic acid sensor.Scientific reports · 2024Article
- Commentary: Curbing myopia progression: The way forward.Indian journal of ophthalmology · 2022Article
- Mass spectrometry analysis of human tear fluid biomarkers specific for ocular and systemic diseases in the context of 3P medicine.The EPMA journal · 2021Review
- Pharmacokinetics and efficacy of a ketorolac-loaded ocular coil in New Zealand white rabbits.Drug delivery · 2021Article
- Diagnostic biomarkers in tear fluid: from sampling to preanalytical processing.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine the levels of dopamine in tear fluid and demonstrate the use of tear fluid as a non-invasive source for dopamine measurements in humans.
methodsThe study cohort included 30 clinically healthy individuals without any pre-existing ocular or systemic conditions. Matched tear fluid (using Schirmer's strips and capillary tubes) and plasma were collected from the subjects. Dopamine levels were evaluated using direct competitive chemiluminescent enzyme-linked immunosorbent assay (ELISA), dopamine kit (Cloud Clone Corp, TX, USA).
resultsSignificantly higher dopamine levels were found in the tear fluid compared to plasma in the study subjects. The level of dopamine was 97.2 ± 11.80 pg/ml (mean ± SEM), 279 ± 14.8 pg/ml (mean ± SEM), and 470.4 ± 37.64 pg/ml (mean ± SEM) in the plasma and in the tears collected using Schirmer's strips and capillary tubes, respectively.
conclusionDopamine was detectable in all the tear fluid samples tested and was also found to be at a higher concentration than in plasma samples. Tear fluid can be used as a non-invasive sample source to monitor dopamine levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.