ArticleeLife2018
Developmental 'awakening' of primary motor cortex to the sensory consequences of movement.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 74 citations in OpenAlex.
- Early adversity alters neurodevelopmental milestones in male and female rat pups and motor cortex morphology and gait in juveniles.Neurobiology of stress · 2026Article
- Motor cortex activity during sleep and wake movements sharpens across development but continues to lag the red nucleus.Scientific reports · 2026Article
- A transient feature of the inferior olive supports the development of cerebellar internal models.bioRxiv : the preprint server for biology · 2025Article
- Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p.eLife · 2025Article
- More Than a Small Brain: The Importance of Studying Neural Function during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Sensorimotor variability distinguishes early features of cognition in toddlers with autism.iScience · 2024Article
- Coincident development and synchronization of sleep-dependent delta in the cortex and medulla.Current biology : CB · 2024Article
- Developmentally Unique Cerebellar Processing Prioritizes Self- over Other-Generated Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Bilateral Whisker Representations in the Primary Somatosensory Cortex in Robo3cKO Mice Are Reflected in the Primary Motor Cortex.Neuroscience · 2024Article
- Developmentally unique cerebellar processing prioritizes self-over other-generated movements.bioRxiv : the preprint server for biology · 2024Article
- DELTA-RHYTHMIC ACTIVITY IN THE MEDULLA DEVELOPS COINCIDENT WITH CORTICAL DELTA IN SLEEPING INFANT RATS.bioRxiv : the preprint server for biology · 2024Article
- Generation and propagation of bursts of activity in the developing basal ganglia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neural decoding reveals specialized kinematic tuning after an abrupt cortical transition.Cell reports · 2023Article
- Infant action and cognition: what's at stake?Trends in cognitive sciences · 2023Article
- Loss of sleep when it is needed most - Consequences of persistent developmental sleep disruption: A scoping review of rodent models.Neurobiology of sleep and circadian rhythms · 2023Article
- Increased glutamatergic synaptic transmission during development in layer II/III mouse motor cortex pyramidal neurons.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Protracted development of motor cortex constrains rich interpretations of infant cognition.Trends in cognitive sciences · 2023Review
- Article
- Axonal connections between S1 barrel, M1, and S2 cortex in the newborn mouse.Frontiers in neuroanatomy · 2023Article
- Transcriptional substrates underlying functional connectivity profiles of subregions within the human sensorimotor cortex.Human brain mapping · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Before primary motor cortex (M1) develops its motor functions, it functions like a somatosensory area. Here, by recording from neurons in the forelimb representation of M1 in postnatal day (P) 8-12 rats, we demonstrate a rapid shift in its sensory responses. At P8-10, M1 neurons respond overwhelmingly to feedback from sleep-related twitches of the forelimb, but the same neurons do not respond to wake-related movements. By P12, M1 neurons suddenly respond to wake movements, a transition that results from opening the sensory gate in the external cuneate nucleus. Also at P12, fewer M1 neurons respond to individual twitches, but the full complement of twitch-related feedback observed at P8 is unmasked through local disinhibition. Finally, through P12, M1 sensory responses originate in the deep thalamorecipient layers, not primary somatosensory cortex. These findings demonstrate that M1 initially establishes a sensory framework upon which its later-emerging role in motor control is built.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.