Evidence map›Paper›PMID 30574775›Full record

ArticleBiochemistry2019

UBC9 Mutant Reveals the Impact of Protein Dynamics on Substrate Selectivity and SUMO Chain Linkages.

Christine M Wright, Robert H Whitaker, Joshua E Onuiri, Tessa Blackburn, Sierra McGarity, Mary-Ann Bjornsti, William J Placzek

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. The Chronic Toxicity of Endocrine-Disrupting Chemical toInternational journal of molecular sciences · 2024
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christine M Wright
Robert H Whitaker
Joshua E Onuiri
Tessa Blackburn
Sierra McGarity
Mary-Ann Bjornsti
William J PlaczekORCID 0000-0003-4096-8617
University of Alabama at Birmingham · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
DNA TOPOISOMERASE-CAMPTOTHECIN INTERACTIONSR01CA058755 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BJORNSTI, MARY-ANN · 1993 to 2011
$3.2M
Training Program in Brain Tumor BiologyT32NS048039 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BENVENISTE, ETTY N · 2007 to 2017
$2.0M
800 MHz NMR Spectrometer for the Central Alabama High-Field NMR FacilityS10RR022994 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KRISHNA, NEPALLI RAMA · 2009 to 2009
$2.0M
Mcl-1 regulation by rBH3 proteins.R01GM117391 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PLACZEK, WILLIAM J. · 2016 to 2020
$1.8M
Howard Hughes Medical InstituteNCI NIH HHS P30 CA013148NCI NIH HHS R01 CA058755NCRR NIH HHS S10 RR022994NIGMS NIH HHS R01 GM117391NINDS NIH HHS T32 NS048039
6 · The paper itself

Abstract

SUMO, a conserved ubiquitin-like protein, is conjugated to a multitude of cellular proteins to maintain genomic integrity and resist genotoxic stress. Studies of the SUMO E2 conjugating enzyme mutant, UBC9

Indexed as

Amino Acid SequenceAmino Acid SubstitutionCatalytic DomainCysteineHumansLeucineMutationProlineSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSequence AlignmentSmall Ubiquitin-Related Modifier ProteinsSubstrate SpecificitySumoylationUbiquitin-Conjugating EnzymesUbiquitin-Conjugating Enzyme UBC9CysteineLeucineProlineSaccharomyces cerevisiae ProteinsSmall Ubiquitin-Related Modifier ProteinsSMT3 protein, S cerevisiaeUbiquitin-Conjugating EnzymesUbiquitin-Conjugating Enzyme UBC9

Identifiers

PMID30574775
PMCPMC6690184
OpenAlexW2905963827

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.