ArticleTuberculosis and respiratory diseases2019
Factors Associated with Indacaterol Response in Tuberculosis-Destroyed Lung with Airflow Limitation.
Article in Tuberculosis and respiratory diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Pathophysiology, clinical manifestation, and treatment of tuberculosis-associated chronic obstructive pulmonary disease: a narrative review.Ewha medical journal · 2025Review
- A scoping review of interventions to address TB associated respiratory disability.EClinicalMedicine · 2024Article
- Analysis of clinical characteristics of different types of lung function impaiement in TDL patients.BMC pulmonary medicine · 2024Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPulmonary tuberculosis can result in anatomical sequelae, and cause airflow limitation. However, there are no treatment guidelines for patients with a tuberculosis-destroyed lung. Recently, indacaterol effectiveness in chronic obstructive pulmonary disease (COPD) patients with Tuberculosis history (INFINITY) study revealed indacaterol provided bronchodilation and symptom improvement in COPD patients with a tuberculosis-destroyed lung.
methodsWe conducted a
resultsOf 62 patients included, 68% were male, and 52% had history of cigarette smoking. Patients revealed mean FEV₁ of 50.5% of predicted value with mean improvement of 81.3 mL in FEV₁ after indacaterol treatment for 8 weeks. Linear regression analysis revealed factors associated with response of FEV₁ to indacaterol included a short duration of smoking history, and high short-acting bronchodilator response. When patients with history of smoking were excluded, factors associated with response of FEV₁ to indacaterol included high short-acting bronchodilator response, and poor healthrelated quality of life score as measured by St. George's Respiratory Questionnaire for COPD.
conclusionIn a tuberculosis-destroyed lung with airflow limitation, short-acting bronchodilator response and smoking history can play a critical role in predicting outcomes of indacaterol treatment.
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