ArticleTemperature (Austin, Tex.)2018
Thyroid stimulating hormone (TSH) autoregulation reduces variation in the TSH response to thyroid hormones.
Article in Temperature (Austin, Tex.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.
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Who cites it
6 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Thyrotropin levels in first-episode bipolar disorder and their association with clinical phenotypes: systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Clinical Parameters Are More Likely to Be Associated with Thyroid Hormone Levels than with Thyrotropin Levels: A Systematic Review and Meta-Analysis.Thyroid : official journal of the American Thyroid Association · 2020Pooled it
- Population data provide evidence against the presence of a set point for hemoglobin levels or tissue oxygen delivery.Physiological reports · 2019Pooled it
- QRFP43 modulates the activity of the hypothalamic-pituitary-thyroid axis in female sheep.Scientific reports · 2025Article
- Redefinition of Successful Treatment of Patients With Hypothyroidism. Is TSH the Best Biomarker of Euthyroidism?Frontiers in endocrinology · 2022Review
- The application of new concepts of the assessment of the thyroid state to pregnant women.Frontiers in endocrinology · 2022Review
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
The physiological functions of Thyroid Stimulating Hormone (TSH) autoregulation, the ultra-short feedback loop inhibition of TSH by TSH itself, have not been determined. In this work we explored the role of TSH autoregulation in thyroid homeostasis. We synthesized the known physiology of autoregulation with theknown physiological relationships between thyroid hormones; in particular between free thyroxine and TSH. We analysed the implications of TSH autoregulation, on the generation of the TSH response to free thyroxine (the 'TSH curve'), and on the variation inthis response, which might result from variations in hypothalamopituitary or thyroid gland function. Our analysis demonstrated that, in the circumstances of inter-individual and intra-individual variations to hypothalamo-pituitary function TSH autoregulation lessens variation in the TSH curve. This in turn enhances the probability of generating and maintaining a euthyroid free thyroxine value. This contribution of TSH autoregulation to the stabilisation of thyroid physiology offers a logical explanation for the evolutionary selection of this physiological process.
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