Autoimmune Ataxia During Maintenance Therapy for Acute Lymphoblastic Leukemia.

Julie Voeller, Chrysanthy Ikonomidou, Justin Brucker, Carol Diamond, Sharon Frierdich, Neha Patel

Open access · hybridAbstract read

In one paragraph

Article in Child neurology open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.2field-weighted citation impact, top 41% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Julie VoellerDivision of Pediatric Hematology, Oncology & Bone Marrow Transplant, Department of Pediatrics, University of Wisconsin, Madison, WI, USA.ORCID https://orcid.org/0000-0001-7811-513X

Chrysanthy IkonomidouSection of Pediatric Neurology, Department of Neurology, University of Wisconsin, Madison, WI, USA.

Justin BruckerSection of Neuroradiology, Department of Radiology, University of Wisconsin, Madison, WI, USA.

Carol DiamondDivision of Pediatric Hematology, Oncology & Bone Marrow Transplant, Department of Pediatrics, University of Wisconsin, Madison, WI, USA.

Sharon FrierdichAmerican Family Children's Hospital, Madison, WI, USA.

Neha PatelDivision of Pediatric Hematology, Oncology & Bone Marrow Transplant, Department of Pediatrics, University of Wisconsin, Madison, WI, USA.

University of Wisconsin–Madison · USUniversity of Wisconsin American Family Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurologic dysfunction during acute lymphoblastic leukemia treatment is commonly associated with chemotherapy. Nonchemotherapy contributions should be considered for persistent atypical symptoms. We describe a boy with acute lymphoblastic leukemia who developed recurrent fevers, diarrhea, progressive ataxia, and neuropsychiatric impairment during maintenance chemotherapy. He was found to have cytomegalovirus in his serum and colon, but not in his cerebrospinal fluid. Instead, his cerebrospinal fluid revealed oligoclonal bands not present in the serum, suggesting an autoimmune process. Prompt treatment with ganciclovir and immunotherapy resulted in marked clinical improvement. Early recognition and treatment of an autoimmune encephalitis is paramount for optimal clinical outcome.

Indexed as

acute lymphoblastic leukemiaautoimmune ataxiaautoimmune encephalitismaintenance chemotherapypediatric

Identifiers

PMID30574519

DOI10.1177/2329048X18819235

PMCPMC6295710

OpenAlexW2904958559

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.