Evidence map›Paper›PMID 30574450›Full record

ArticleCurrent clinical microbiology reports2018

Genetic tools for investigating Mucorales fungal pathogenesis.

Alexis Garcia, Sandeep Vellanki, Soo Chan Lee

Abstract read
In one paragraph

Article in Current clinical microbiology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. mBio · 2023
    Article
  4. Mucormycosis in 2023: an update on pathogenesis and management.Frontiers in cellular and infection microbiology · 2023
    Review
  5. Review
  6. CRISPR-Cas9-Based Mutagenesis of the Mucormycosis-Causing FungusInternational journal of molecular sciences · 2020
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alexis GarciaSouth Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, the University of Texas at San Antonio, San Antonio, TX 78249, USA.
Sandeep VellankiSouth Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, the University of Texas at San Antonio, San Antonio, TX 78249, USA.
Soo Chan LeeSouth Texas Center for Emerging Infectious Diseases (STCEID), Department of Biology, the University of Texas at San Antonio, San Antonio, TX 78249, USA.
Texas Center for Infectious Disease · USThe University of Texas at San Antonio · US

Funding

Improvement of genetic analysis in the pathogenic zygomycete Mucor circinelloidesR03AI119617 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI LEE, SOO CHAN · 2016 to 2017
$150k
NIAID NIH HHS R03 AI119617
6 · The paper itself

Abstract

purpose of reviewMucormycosis is an emerging opportunistic fungal infection whose causative agents are found within the Mucorales family. A recent increase in immunocompromised cohorts with solid organ transplants, diabetes mellitus, and other medical conditions have resulted in increased fungal infections including mucormycosis. Our current knowledge about Mucoralean fungi is in its infancy compared to other fungal pathogens, which may be due to lack of robust genetic tools for Mucorales. In this review we summarize recent advances in genetic tools to study the two most prevalent and genetically amenable Mucoralean fungi, RECENT

findingsThere have been advances made in the study of Mucorales family genetics. These findings include the construction of recyclable markers to manipulate the genome, as well as silencing vectors, and the adaptation of the CRISPR/Cas9 gene editing system. SUMMARY: We present how these genetic methods have been applied to understand basic biology, morphogenesis, pathogenesis, and host-pathogen interactions in the two Mucoralean fungi,

Indexed as

CRISPR/Cas9 in fungiMucormucormycosisrecyclable markerRhizopus

Identifiers

PMID30574450
PMCPMC6296817
OpenAlexW2809330832

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.