ArticleGlobal spine journal2018
Presentation and Outcomes After Medical and Surgical Treatment Versus Medical Treatment Alone of Spontaneous Infectious Spondylodiscitis: A Systematic Literature Review and Meta-Analysis.
Article in Global spine journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Understanding the management of pediatric spondylodiscitis based on existing literature; a systematic review.BMC pediatrics · 2023Pooled it
- Operative and antibiotic treatment of cervical spondylodiscitis: a retrospective bicentric outcome analysis.Acta neurochirurgica · 2026Article
- From Culture to Sequencing: Evolving Strategies for the Diagnosis of Pediatric Spondylodiscitis.Orthopaedic surgery · 2026Review
- Early and late mortality in vertebral osteomyelitis: who dies within the first year after diagnosis.Infection · 2025Article
- Surgical treatment of unstable spondylodiscitis with posterior instrumentation and bioactive glass (BAG-S53P4): surgical technique and results at medium-term follow-up.Journal of spine surgery (Hong Kong) · 2025Article
- Cervical Pyogenic Spondylitis: A Comprehensive Review of Diagnosis and Treatment Strategy.Journal of clinical medicine · 2025Review
- Review
- Medical versus surgical treatment of spondylodiscitis: does surgery spare resources?Neurosurgical review · 2025Article
- Lumbar spondylodiscitis attributed to a rare infection withRadiology case reports · 2024Article
- Multimodal management for low-back pain associated with spondylodiscitis.Medicine and pharmacy reports · 2024Article
- Regional Spondylodiscitis Disparities: Impact on Pathogen Spectrum and Patients.Journal of clinical medicine · 2024Article
- An investigation into the quality of life improvements after vertebral osteomyelitis depending on the status of pathogen detection.Acta orthopaedica et traumatologica turcica · 2024Article
- Anterior Column Reconstruction of Destructive Vertebral Osteomyelitis at the Thoracolumbar Spine with an Expandable Vertebral Body Replacement Implant: A Retrospective, Monocentric Radiological Cohort Analysis of 24 Cases.Journal of clinical medicine · 2024Article
- Cervical spine spondylodiscitis: Review of literature on current treatment strategies.Heliyon · 2023Review
- The impact of concomitant infective endocarditis in patients with spondylodiscitis and isolated spinal epidural empyema and the diagnostic accuracy of the modified duke criteria.Frontiers in surgery · 2023Article
- Cervical epidural abscess complicated by a pharyngoesophageal perforation after anterior cervical spine surgery for subaxial spondylodiscitis.Surgical neurology international · 2023Article
- Spinal infection with intraspinal abscess or empyema and acute myelopathy: comparative analysis of diagnostics, therapy, complications and outcome in primary care.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Unexpectedly rapid decrease in the size of a spinal epidural abscess after percutaneous posterior pedicle screw fixation without decompression surgery: a case report.Spinal cord series and cases · 2022Article
- Incidence, risk factors and clinical course of pyogenic spondylodiscitis patients with pulmonary embolism.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- CORR Insights®: Treatment Guideline for Patients with Native Culture-negative Pyogenic Vertebral Osteomyelitis.Clinical orthopaedics and related research · 2022Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designSystematic literature review.
objectivesThe aims of this study were to (1) describe the clinical features, disabilities, and incidence of neurologic deficits of pyogenic spondylodiscitis prior to treatment and (2) compare the functional outcomes between patients who underwent medical treatment alone or in combination with surgery for pyogenic spondylodiscitis.
methodsA systematic literature review was performed using PubMed according to PRISMA guidelines. No year restriction was put in place. Statistical analysis of pooled data, when documented in the original report (ie, number of patients with desired variable and number of patients evaluated), was conducted to determine the most common presenting symptoms, incidence of pre- and postoperative neurologic deficits, associated comorbidities, infectious pathogens, approach for surgery when performed, and duration of hospitalization. Outcomes data, including return to work status, resolution of back pain, and functional recovery were also pooled among all studies and surgery-specific studies alone. Meta-analysis of studies with subgroup analysis of pain-free outcome in surgical and medical patients was performed.
resultsFifty of 1286 studies were included, comprising 4173 patients undergoing either medical treatment alone or in combination with surgery. Back pain was the most common presenting symptom, reported in 91% of patients. Neurologic deficit was noted in 31% of patients.
conclusionMedical management remains first-line treatment of infectious pyogenic spondylodiscitis. Surgery may be indicated for progressive pain, persistent infection on imaging, deformity or neurologic deficits. If surgery is required, reported literature shows potential for significant pain reduction, improved neurologic function and a high number of patients returning to a normal functional/work status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.