ArticleAging and disease2018
Age-Related Changes in Femoral Head Trabecular Microarchitecture.
Article in Aging and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Methods for bone quality assessment in human bone tissue: a systematic review.Journal of orthopaedic surgery and research · 2022Pooled it
- How do forelimb long bones adapt in rhinoceroses? An in-depth examination of their microanatomy.Journal of anatomy · 2026Article
- Vertebral trabecular microarchitecture changes in the normally ageing population.Quantitative imaging in medicine and surgery · 2026Article
- Stochastic parametric skeletal dosimetry model for humans: Anatomical-morphological basis and parameter evaluation.PloS one · 2025Article
- Quantitative Analysis of Primary Compressive Trabeculae Distribution in the Proximal Femur of the Elderly.Orthopaedic surgery · 2024Article
- l-arginine promotes angio-osteogenesis to enhance oxidative stress-inhibited bone formation by ameliorating mitophagy.Journal of orthopaedic translation · 2024Article
- Predicting the Fracture Toughness of Human Cancellous Bone in Fractured Neck of Femur Patients Using Bone Volume and Micro-Architecture.Life (Basel, Switzerland) · 2024Article
- Sex Differentiation of Trabecular Bone Structure Based on Textural Analysis of Pelvic Radiographs.Journal of clinical medicine · 2024Article
- Conical shell X-ray beam tomosynthesis and micro-computed tomography for microarchitectural characterisation.Scientific reports · 2023Article
- Bone marrow mesenchymal stem cell-derived exosomal microRNA-382 promotes osteogenesis in osteoblast via regulation of SLIT2.Journal of orthopaedic surgery and research · 2023Article
- Article
- A highly generalized classifier for osteoporosis radiography based on multiscale fractal, lacunarity, and entropy distributions.Frontiers in bioengineering and biotechnology · 2023Article
- Studying trabecular bone samples demonstrates a power law relation between deteriorated structure and mechanical properties - a study combining 3D printing with the finite element method.Frontiers in endocrinology · 2023Article
- Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints.Scientific reports · 2022Article
- Gut Microbiome Signature Are Correlated With Bone Mineral Density Alterations in the Chinese Elders.Frontiers in cellular and infection microbiology · 2022Article
- Elemental Composition in Female Dry Femora Using Portable X-Ray Fluorescence (pXRF): Association with Age and Osteoporosis.Calcified tissue international · 2021Article
- Influence of thermodisinfection on microstructure of human femoral heads: duration of heat exposition and compressive strength.Cell and tissue banking · 2020Article
- Age-Related Trends in the Trabecular Micro-Architecture of the Medial Clavicle: Is It of Use in Forensic Science?Frontiers in bioengineering and biotechnology · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis is a prevalent bone condition, characterised by low bone mineral density and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of bone mineral density using dual energy X-ray absorption. However, many studies have shown that bone strength, and consequently the probability of fracture, is a combination of both bone mass and bone 'quality' (architecture and material chemistry). Although the microarchitecture of both non-fracture and osteoporotic bone has been previously investigated, many of the osteoporotic studies are constrained by factors such as limited sample number, use of ovariectomised animal models, and lack of male and female discrimination. This study reports significant differences in bone quality with respect to the microarchitecture between fractured and non-fractured human femur specimens. Micro-computed tomography was utilised to investigate the microarchitecture of femoral head trabecular bone from a relatively large cohort of non-fracture and fracture human donors. Various microarchitectural parameters have been determined for both groups, providing an understanding of the differences between fracture and non -fracture material. The microarchitecture of non-fracture and fracture bone tissue is shown to be significantly different for many parameters. Differences between sexes also exist, suggesting differences in remodelling between males and females in the fracture group. The results from this study will, in the future, be applied to develop a fracture model which encompasses bone density, architecture and material chemical properties for both female and male tissues.
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