Evidence map›Paper›PMID 30574216›Full record

ArticleEuropean geriatric medicine2018

Predictive validity of the CriSTAL tool for short-term mortality in older people presenting at Emergency Departments: a prospective study.

Magnolia Cardona, Ebony T Lewis, Mette R Kristensen, Helene Skjøt-Arkil, Anette Addy Ekmann, Hanne H Nygaard, Jonas J Jensen, Rune O Jensen, Jonas L Pedersen, Robin M Turner and 16 more

Open access · hybridAbstract read
In one paragraph

Article in European geriatric medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Pooled it
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  12. Development of an emergency department end of life care audit tool: A scoping review.International journal of nursing studies advances · 2023
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  20. External Prospective Validation of the Modified CriSTAL Score for 30- and 90-day Mortality in Geriatric Urgent Surgical Patients.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 16 institutions in 3 countries.

Magnolia CardonaCentre for Research in Evidence-Based Practice, Faculty of Health Sciences and Medicine, Bond University, Robina, QLD, Australia. mcardona@bond.edu.au.
Ebony T LewisSchool of Public Health and Community Medicine, The University of New South Wales, Sydney, NSW, Australia.
Mette R KristensenHospital of South West Jutland, Esbjerg, South Jutland, Denmark.
Helene Skjøt-ArkilDepartment of Emergency Medicine, Hospital of Southern Jutland, and Institute of Regional Health Research, University of Southern Denmark, Aabenraa, Denmark.
Anette Addy EkmannDepartment of Continuous Patient Progress, Bispebjerg og Frederiksberg Hospital, Copenhagen, Denmark.
Hanne H NygaardDepartment of Emergency Medicine, Bispebjerg og Frederiksberg Hospital, Copenhagen, Denmark.
Jonas J JensenOdense University Hospital, Odense, Fyn, Denmark.
Rune O JensenOdense University Hospital, Odense, Fyn, Denmark.
Jonas L PedersenOdense University Hospital, Odense, Fyn, Denmark.
Robin M TurnerDean's Office Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Frances GardenIngham Institute for Applied Medical Research, Liverpool, NSW, Australia.
Hatem AlkhouriAgency for Clinical Innovation, Emergency Care Institute, Chatswood, NSW, Australia.
Stephen AshaSt George Hospital Emergency Department, Kogarah, NSW, Australia.
John MackenziePrince of Wales Hospital Emergency Department, Randwick, NSW, Australia.
Margaret PerkinsCampbelltown Hospital Emergency Department, Campbelltown, NSW, Australia.
Sam SuriCampbelltown Hospital Intensive Care Unit, Campbelltown, NSW, Australia.
Anna HoldgateLiverpool Hospital Emergency Department, Liverpool, NSW, Australia.
Luis WinotoSutherland Hospital Emergency Department, Sutherland, NSW, Australia.
David C W ChangGraduate School of Biomedical Engineering, The University of New South Wales, Kensington, NSW, Australia.
Blanca Gallego-LuxanCentre for Health Informatics, Australian Institute of Health Innovation, Macquarie University, Sydney, NSW, Australia.
Sally McCarthyPrince of Wales Hospital Emergency Department, Randwick, NSW, Australia.
John A PetersenDepartment of Emergency Medicine, Bispebjerg og Frederiksberg Hospital, Copenhagen, Denmark.
Birgitte N JensenDepartment of Emergency Medicine, Bispebjerg og Frederiksberg Hospital, Copenhagen, Denmark.
Christian Backer MogensenDepartment of Emergency Medicine, Hospital of Southern Jutland, and Institute of Regional Health Research, University of Southern Denmark, Aabenraa, Denmark.
Ken HillmanLiverpool Hospital Intensive Care Unit, Liverpool, NSW, Australia.
Mikkel BrabrandHospital of South West Jutland, Esbjerg, South Jutland, Denmark.
Frederiksberg Hospital · DKOdense University Hospital · DKCamden and Campbelltown Hospitals · AUPrince of Wales Hospital · AUUNSW Sydney · AUBond University · AUHospital South West Jutland · DKIngham Institute · AULiverpool Hospital · AUMacquarie University · AUSouth Western Sydney Local Health District · AUSt George Hospital · AUSutherland Hospital · AUSygehus Sønderjylland · DKUniversity of Otago · NZUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractTo determine the validity of the Australian clinical prediction tool Criteria for Screening and Triaging to Appropriate aLternative care (CRISTAL) based on objective clinical criteria to accurately identify risk of death within 3 months of admission among older patients.

methodsProspective study of ≥ 65 year-olds presenting at emergency departments in five Australian (Aus) and four Danish (DK) hospitals. Logistic regression analysis was used to model factors for death prediction; Sensitivity, specificity, area under the ROC curve and calibration with bootstrapping techniques were used to describe predictive accuracy.

results2493 patients, with median age 78-80 years (DK-Aus). The deceased had significantly higher mean CriSTAL with Australian mean of 8.1 (95% CI 7.7-8.6 vs. 5.8 95% CI 5.6-5.9) and Danish mean 7.1 (95% CI 6.6-7.5 vs. 5.5 95% CI 5.4-5.6). The model with Fried Frailty score was optimal for the Australian cohort but prediction with the Clinical Frailty Scale (CFS) was also good (AUROC 0.825 and 0.81, respectively). Values for the Danish cohort were AUROC 0.764 with Fried and 0.794 using CFS. The most significant independent predictors of short-term death in both cohorts were advanced malignancy, frailty, male gender and advanced age. CriSTAL's accuracy was only modest for in-hospital death prediction in either setting.

conclusionsThe modified CriSTAL tool (with CFS instead of Fried's frailty instrument) has good discriminant power to improve prognostic certainty of short-term mortality for ED physicians in both health systems. This shows promise in enhancing clinician's confidence in initiating earlier end-of-life discussions.

Indexed as

AgedFrailPrognosisProspective studiesRisk assessmentUncertainty

Identifiers

PMID30574216
PMCPMC6267649
OpenAlexW2899149190

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.