ArticleClinical medicine insights. Gastroenterology2018
Melanosis Coli: A Helpful Contrast Effect or a Harmful Pigmentation?
Article in Clinical medicine insights. Gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Colorectal neoplasms in melanosis coli: a survey in Japan and a worldwide meta-analysis.International journal of colorectal disease · 2021Pooled it
- TRPV4-Dependent Epithelial Mechanoadaptation and Barrier Remodeling Mediate Sennoside-Induced Distal Colonic Motility.International journal of molecular sciences · 2026Article
- Colonoscopic Resolution of Melanosis Coli After Cessation of Senna Laxative Use.International medical case reports journal · 2024Article
- Review on melanosis coli and anthraquinone-containing traditional Chinese herbs that cause melanosis coli.Frontiers in pharmacology · 2023Review
- Intraoperative discovery of melanosis coli during emergent bowel resection for perforation.BMJ case reports · 2022Article
- Severe grade of melanosis coli is associated with a higher detection rate of colorectal adenoma.Journal of clinical biochemistry and nutrition · 2022Article
- Melanosis coli: A factor not associated with histological progression of colorectal polyps.Journal of digestive diseases · 2022Article
- Pseudomelanosis coli, its relation to laxative use and association with colorectal neoplasms: A comprehensive review.JGH open : an open access journal of gastroenterology and hepatology · 2021Review
- Differential proteomics mass spectrometry of melanosis coli.American journal of translational research · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMelanosis coli, a brown discoloration of colonic mucosa, is considered as a benign condition mainly observed in patients under chronic anthranoid laxatives. Recent data link this condition with an increased adenoma detection rate. Moreover, its tumorigenic potential and possible association with the development of colorectal cancer remains uncertain. We conducted this study to compare the polyp detection rate and colorectal cancer diagnosis in patients with melanosis against matched control group without melanosis. PATIENTS AND
methodsA retrospective single-center study. Patients diagnosed with melanosis coli on colonoscopy over a 15-year period were included. Each melanosis coli patient was matched with three controls by age, gender, setting (inpatient/outpatient), and procedure's indication. Polyp detection rate and diagnosis of colorectal cancer were recorded and compared between the groups before and after adjustment for bowel preparation.
resultsA cohort of 718 patients with melanosis and 2154 controls were included. The polyp detection rates were 33.4% and 21.8% of melanosis and control groups, respectively (
conclusionsMelanosis coli is not associated with increased diagnosis of colorectal cancer. It is associated, however, with enhanced polyp detection likely due to chromo-endoscopy-like effect.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.