Evidence map›Paper›PMID 30573980›Full record

ArticleOncoTargets and therapy2018

Coincident primary breast lymphoma and gastrointestinal stromal tumor: case series and molecular mechanisms.

Ethan B Ludmir, Tyler Gutschenritter, Chelsea C Pinnix, Jillian R Gunther, Loretta J Nastoupil, Joseph D Khoury, L Jeffrey Medeiros, Bouthaina S Dabaja, Sarah A Milgrom

Open access · goldAbstract read
In one paragraph

Article in OncoTargets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ethan B LudmirDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, samilgrom@mdanderson.org.
Tyler GutschenritterDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, samilgrom@mdanderson.org.
Chelsea C PinnixDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, samilgrom@mdanderson.org.
Jillian R GuntherDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, samilgrom@mdanderson.org.
Loretta J NastoupilDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Joseph D KhouryDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
L Jeffrey MedeirosDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Bouthaina S DabajaDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, samilgrom@mdanderson.org.
Sarah A MilgromDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, samilgrom@mdanderson.org.
The University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastrointestinal stromal tumor (GIST) is an uncommon mesenchymal tumor, and has been shown to be associated with synchronous or metachronous second malignancies. Rare cases of coincident GIST and non-Hodgkin lymphomas (NHL) have been reported previously. Here, we report two cases of GIST and coincident primary breast lymphoma, an uncommon subtype of extranodal NHL. We propose that the exceedingly low likelihood of both these cancers occurring in these two patients by chance warrants examination for possible common oncogenic pathways in these lesions, possibly involving shared anti-apoptotic mechanisms. Further research is vital to elucidate common oncogenic pathways between such rare lesions.

Indexed as

anti-apoptosisdiffuse large B-cell lymphomagastrointestinal stromal tumormucosa-associated lymphoid tissue lymphomaprimary breast lymphoma

Identifiers

PMID30573980
PMCPMC6292410
OpenAlexW2905269633

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.