ReviewTherapeutics and clinical risk management2018
Reevaluation and update on efficacy and safety of neostigmine for reversal of neuromuscular blockade.
Review in Therapeutics and clinical risk management, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neostigmine and Glycopyrrolate for the Treatment of Post Dural Puncture Headache After Known Dural Puncture With a Tuohy Needle: A Pilot Study
Effect of the Use of Atracurium With or Without Reversal Agent on Haemodynamic Parameters During Extubation: a Randomized Controlled Trial
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Comparing sugammadex to neostigmine and their effects on delirium and postoperative cognitive function: A systematic review.Journal of perioperative practice · 2026Pooled it
- Sugammadex and intraocular pressure: systematic review with meta-analysis and trial sequential analysis.BMC anesthesiology · 2026Pooled it
- The effect of glycopyrrolate vs. atropine in combination with neostigmine on cardiovascular system for reversal of residual neuromuscular blockade in the elderly: a randomized controlled trial.BMC anesthesiology · 2024Trial
- Effect of patient decision aids on choice between sugammadex and neostigmine in surgeries under general anesthesia: a multicenter randomized controlled trial.Korean journal of anesthesiology · 2023Trial
- Administration of neostigmine after tracheal intubation shortens time to successful intraoperative neuromonitoring during thyroid surgery: a randomized controlled trial.Scientific reports · 2022Trial
- In-depth exploration of sugammadex and novel neuromuscular blockade antagonists: a narrative review.Frontiers in pharmacology · 2026Review
- Noncardiogenic Pulmonary Edema After Neostigmine Administration During Emergence From General Anesthesia: A Case Report.Case reports in anesthesiology · 2026Article
- Sugammadex in Perioperative Neuromuscular Management: Current Advances and Best Practices.Current pharmaceutical design · 2026Review
- Pediatric Anesthetic Management of a Patient With Warburg Micro Syndrome, a Rare Autosomal Recessive Genetic Disorder.Clinical case reports · 2025Article
- Age-Specific Pharmacology of Neuromuscular Blocking Agents: A Comprehensive Review.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Intractable Neuromuscular Blockade Resistant to Sugammadex Rescue Administration: A Case Report.Cureus · 2025Article
- Article
- Bidirectional endoscopic and pharmacological approach for the treatment of severe right-sided colonic stool impaction.BMJ case reports · 2025Article
- Neuromuscular Blockade Antagonism for Thyroid Surgery During Intraoperative Neural Monitoring-An Anesthesia Perspective.Medicina (Kaunas, Lithuania) · 2025Review
- Non-neuronal cholinergic stimulation favors bone mass accrual.Frontiers in physiology · 2025Article
- Neurologic Examination Facilitated by Reversal of Rocuronium with Sugammadex.Journal of pharmacy practice · 2024Article
- New advances in clinical application of neostigmine: no longer focusing solely on increasing skeletal muscle strength.Frontiers in pharmacology · 2023Review
- Optimizing Reversal of Neuromuscular Block in Older Adults: Sugammadex or Neostigmine.Drugs & aging · 2022Article
- Flexible organic frameworks sequester neuromuscular blocking agentsChemical science · 2022Article
- A novel use of neostigmine reversal for intraoperative neural monitoring during thyroid surgery.The Kaohsiung journal of medical sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative residual neuromuscular block is a serious threat which endangers the patient safety. Neostigmine has been the most commonly used anticholinesterase for the pharmacological reversal of neuromuscular blockade. Although newer agents have been introduced recently, neostigmine has some irreplaceable advantages, including broad-spectrum reversal of all nondepolarizing neuromuscular blocking drugs, low cost, and availability of more related data for clinical practice to refer to. Neostigmine is also noticed to have some drawbacks, such as the inability to reverse profound and deep blockade, potential induction of muscle weakness, cardiovascular adverse effects, and so on. Data on the usage of neostigmine in the geriatric and the pediatric population are still insufficient. Some discrepancies are observed in the results from previous studies which need further investigation. However, recent studies offer some renewed information. Regarding both efficacy and safety, the key for successful reversal of neuromuscular blockade is to use neostigmine "appropriately," optimizing the dosage and timing of administration under close monitoring.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.