Evidence map›Paper›PMID 30573937›Full record

ArticleIntelligence

Age-Moderation of Genetic and Environmental Contributions to Cognitive Functioning in Mid- and Late-Life for Specific Cognitive Abilities.

Shandell Pahlen, Nayla R Hamdi, Anna K Dahl Aslan, Briana N Horwitz, Matthew S Panizzon, Inge Petersen, Catalina Zavala, Kaare Christensen, Deborah Finkel, Carol E Franz and 8 more

Abstract read
In one paragraph

Article in Intelligence. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019
    Trial
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  3. The Interplay of Genes and Environment Across Multiple Studies (IGEMS) Consortium After Fifteen Years.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Shandell PahlenDepartment of Psychology, University of Minnesota, Minneapolis, MN 55455, USA.
Nayla R HamdiDepartment of Psychology, University of Minnesota, Minneapolis, MN 55455, USA.
Anna K Dahl AslanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm SE-17177, Sweden.
Briana N HorwitzDepartment of Psychology, California State University Fullerton, Fullerton, CA 92834, USA.
Matthew S PanizzonDepartment of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
Inge PetersenThe Danish Twin Register, The Danish Aging Research Center, University of Southern Denmark, DK-5000 Odense C, Denmark.
Catalina ZavalaDepartment of Psychology, University of California Riverside, Riverside, CA 92521, USA.
Kaare ChristensenThe Danish Twin Register, The Danish Aging Research Center, University of Southern Denmark, DK-5000 Odense C, Denmark.
Deborah FinkelDepartment of Psychology, Indiana University Southeast, New Albany, IN 47150, USA.
Carol E FranzDepartment of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
Margaret GatzDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm SE-17177, Sweden.
Wendy JohnsonDepartment of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Midlothian, Scotland, UK.
William S KremenDepartment of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
Robert F KruegerDepartment of Psychology, University of Minnesota, Minneapolis, MN 55455, USA.
Jenae M NeiderhiserDepartment of Psychology, Penn State University, University Park, PA 16802, USA.
Chandra A ReynoldsDepartment of Psychology, University of California Riverside, Riverside, CA 92521, USA.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm SE-17177, Sweden.
Matt McGueDepartment of Psychology, University of Minnesota, Minneapolis, MN 55455, USA.

Funding

U19 MIDlife in the United States-Diversity Supplement-WellsU19AG051426 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAROL D. RYFF · 2016 to 2026
$74.8M
STATISTICS COREP01AG020166 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RYFF, CAROL D. · 2002 to 2015
$50.6M
The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
TRAJECTORIES OF MORTALITY IN CAENORHABDITIS ELEGANSP01AG008761 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ROACH, DEBORAH A · 1990 to 2008
$17.5M
THE RANGE OF MALE-FEMALE MORTALITY DIFFERENCESP01AG031719 · NIA · DUKE UNIVERSITY · PI ZENG, YI · 2009 to 2020
$10.2M
The VETSA Longitudinal Twin Study of Cognition and AgingR01AG018384 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LYONS, MICHAEL J. · 2002 to 2012
$9.8M
The VETSA longitudinal twin study of cognition and agingR01AG018386 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2002 to 2012
$9.7M
The VETSA Longitudinal MRI Twin Study of Aging (VETSA MRI 4)R01AG076838 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE, Jeremy A Elman · 2022 to 2026
$8.7M
Gene-Environment Interplay of Social Contexts and Aging-Related OutcomesR01AG037985 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 2010 to 2014
$3.2M
GENETIC &ENVIRONMENTAL INFLUENCES--BIOBEHAVIORAL AGINGR01AG010175 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 1992 to 2006
$2.8M
GENES, ENVIRONMENT, AND MATERNAL ADJUSTMENTR01MH054610 · NIMH · GEORGE WASHINGTON UNIVERSITY · PI NEIDERHISER, JENAE M. · 1996 to 2006
$2.7M
NIA NIH HHS P01 AG008761NIA NIH HHS P01 AG020166NIA NIH HHS P01 AG031719NIA NIH HHS R01 AG010175NIA NIH HHS R01 AG018384NIA NIH HHS R01 AG018386NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG022982NIA NIH HHS R01 AG037985NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG076838NIA NIH HHS R56 AG037985NIA NIH HHS U19 AG051426NIMH NIH HHS R01 MH054610
6 · The paper itself

Abstract

Age moderation of genetic and environmental contributions to Digits Forward, Digits Backward, Block Design, Symbol Digit, Vocabulary, and Synonyms was investigated in a sample of 14,534 twins aged 26 to 98 years. The Interplay of Genes and Environment across Multiple Studies (IGEMS) consortium contributed the sample, which represents nine studies from three countries (USA, Denmark, and Sweden). Average test performance was lower in successively older age groups for all tests. Significant age moderation of additive genetic, shared environmental, and non-shared environmental variance components was observed, but the pattern varied by test. The genetic contribution to phenotypic variance across age was smaller for both Digit Span tests, greater for Synonyms, and stable for Block Design and Symbol Digit. The non-shared environmental contribution was greater with age for the Digit Span tests and Block Design, while the shared environmental component was small for all tests, often more so with age. Vocabulary showed similar age-moderation patterns as Synonyms, but these effects were nonsignificant. Findings are discussed in the context of theories of cognitive aging.

Indexed as

Adult DevelopmentAgingBehavior GeneticsCognitive Ability

Identifiers

PMID30573937
PMCPMC6296772

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.