Evidence map›Paper›PMID 30573762›Full record

ArticleScientific reports2018

Different pro-angiogenic potential of γ-irradiated PBMC-derived secretome and its subfractions.

Tanja Wagner, Denise Traxler, Elisabeth Simader, Lucian Beer, Marie-Sophie Narzt, Florian Gruber, Sibylle Madlener, Maria Laggner, Michael Erb, Vera Vorstandlechner and 10 more

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Head and neck squamous cell carcinoma: current and emerging therapeutic strategies.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
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  17. Mesenchymal Stem Cell Secretome for Dermatology Application: A Review.Clinical, cosmetic and investigational dermatology · 2021
    Review
  18. Article
  19. Article
  20. Quantitative Hybrid Cardiac [Molecular therapy. Methods & clinical development · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Tanja WagnerDivision of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.
Denise TraxlerDepartment of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0001-8679-1525
Elisabeth SimaderDivision of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.
Lucian BeerDepartment of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Marie-Sophie NarztResearch Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria.
Florian GruberResearch Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0003-1094-5641
Sibylle MadlenerMolecular Neuro-Oncology Research Unit, Department of Pediatrics and Adolescent Medicine and Institute of Neurology, Medical University of Vienna, Vienna, Austria.
Maria LaggnerDivision of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.
Michael ErbSynlab, Birsfelden, Switzerland.
Vera VorstandlechnerDivision of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.
Alfred GugerellDivision of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-5178-9967
Christine RadtkeClinical Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.
Massimiliano GnecchiDepartment of Molecular Medicine, Unit of Cardiology, University of Pavia, Pavia, Italy.
Anja PeterbauerRed Cross Blood Transfusion Service of Upper Austria, Linz, Austria.
Maria GschwandtnerResearch Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria.
Erwin TschachlerResearch Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria.
Claudia KeiblLudwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria.
Paul SlezakLudwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria.
Hendrik J AnkersmitDivision of Thoracic Surgery, Medical University of Vienna, Vienna, Austria. hendrik.ankersmit@meduniwien.ac.at.
Michael MildnerResearch Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna, Austria. michael.mildner@meduniwien.ac.at.ORCID http://orcid.org/0000-0002-6892-925X

Funding

Österreichische Forschungsförderungsgesellschaft (Austrian Research Promotion Agency) 852748Christian Doppler Forschungsgesellschaft (Christian Doppler Research Association) 2009-2015
6 · The paper itself

Abstract

Secretomes from various cell sources exert strong regenerative activities on numerous organs, including the skin. Although secretomes consist of many diverse components, a growing body of evidence suggests that small extracellular vesicles (EVs) account for their regenerative capacity. We previously demonstrated that the secretome of γ-irradiated peripheral blood mononuclear cells (PBMCs) exhibits wound healing capacity. Therefore, we sought to dissect the molecular composition of EVs present in the secretome and compared wound healing-related activities of these EVs to other subfractions of the secretome and the fully supplemented secretome (MNC

Indexed as

Extracellular VesiclesGamma RaysProteomeA549 CellsAnimalsCells, CulturedChemical FractionationCulture Media, ConditionedDiabetes Mellitus, ExperimentalHumansLeukocytes, MononuclearMiceMice, Inbred C57BLMice, TransgenicNeovascularization, PhysiologicSecretory PathwayCulture Media, ConditionedProteome

Identifiers

PMID30573762
PMCPMC6301954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.